deltatrials
Completed PHASE2 INTERVENTIONAL 8-arm NCT03917654

Pfs230D1M-EPA/AS01 Vaccine, a Transmission Blocking Vaccine Against Plasmodium Falciparum, in an Age De-Escalation Trial of Children and a Family Compound Trial in Mali

Safety, Immunogenicity and Efficacy of Pfs230D1M-EPA/AS01 Vaccine, a Transmission Blocking Vaccine Against Plasmodium Falciparum, in an Age De-Escalation Trial of Children and a Family Compound Trial in Mali

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Conditions Malaria
Interventions AVAXIM HAVRIX Menactra Pfs230D1M-EPA/AS01 TYPHIM Vi (Salmonella typhi vaccine)
Updated 25 times since 2019 Last updated: Oct 1, 2024 Started: Apr 24, 2019 Primary completion: Jul 30, 2021 Completion: Oct 31, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03917654, this PHASE2 trial focuses on Malaria and remains completed. Sponsored by National Institute of Allergy and Infectious Diseases (NIAID), it has been updated 25 times since 2019, reflecting substantial change activity. This study is part of the global effort to build evidence for infectious disease interventions.

Status Flow

~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~Sep 2020 · 5 months · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Sep 2021 · 6 months · monthly snapshot~Sep 2021 – ~Dec 2021 · 3 months · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Sep 2022 · 8 months · monthly snapshot~Sep 2022 – ~Apr 2023 · 7 months · monthly snapshot~Apr 2023 – ~Jul 2024 · 15 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – present · 20 months · monthly snapshot

Change History

25 versions recorded

  1. Nov 2024 — Present [monthly]

    Completed PHASE2

  2. Sep 2024 — Nov 2024 [monthly]

    Completed PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  4. Apr 2023 — Jul 2024 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  5. Sep 2022 — Apr 2023 [monthly]

    Active Not Recruiting PHASE2

▶ Show 20 earlier versions

  1. Jan 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

  2. Dec 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE2

  3. Sep 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE2

  4. Mar 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE2

  5. Feb 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE2

  6. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE2

  7. Oct 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  8. Sep 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE2

  9. Apr 2020 — Sep 2020 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  10. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE2

  11. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE2

  12. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE2

  13. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  14. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

  15. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE2

  16. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE2

  17. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE2

  18. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE2

  19. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE2

  20. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE2

    First recorded

Apr 2019

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Institute of Allergy and Infectious Diseases (NIAID)
Data source: National Institutes of Health Clinical Center (CC)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations