Electroconvulsive Therapy (ECT) for Agitation in Dementia (AD) (ECT-AD)
Effect and Safety of Electroconvulsive Therapy Plus Usual Care for the Acute Management of Severe Agitation in Dementia
Sponsor: Brent Forester
This observational or N/A phase trial investigates Agitation,Psychomotor and Alzheimer Dementia and is currently actively recruiting participants. Brent Forester leads this study, which shows 13 recorded versions since 2021 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.
Study Description(click to expand)This study will be a single-arm, unblinded, non-randomized trial to determine the effect and safety of ECT for severe agitation in moderate to severe stage dementia, while also examining the durability of the acute treatment effect in an exploratory maintenance naturalistic design. We plan to enroll 50 participants with an estimated dropout rate of 20%. We expect 50 participants to complete at least 1 ECT treatment before moving into the 12-month naturalistic follow-up phase.
This study will be a single-arm, unblinded, non-randomized trial to determine the effect and safety of ECT for severe agitation in moderate to severe stage dementia, while also examining the durability of the acute treatment effect in an exploratory maintenance naturalistic design. We plan to enroll 50 participants with an estimated dropout rate of 20%. We expect 50 participants to complete at least 1 ECT treatment before moving into the 12-month naturalistic follow-up phase.
Status Flow
Change History
13 versions recorded-
May 4, 2026 — Present [daily]
Recruiting
Phase: NA → None
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Sep 2024 — May 2026 [monthly]
Recruiting NA
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Jul 2024 — Sep 2024 [monthly]
Recruiting NA
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Nov 2023 — Jul 2024 [monthly]
Recruiting NA
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Jul 2022 — Nov 2023 [monthly]
Recruiting NA
▶ Show 8 earlier versions
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May 2022 — Jul 2022 [monthly]
Recruiting NA
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May 2021 — May 2022 [monthly]
Recruiting NA
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Mar 2021 — May 2021 [monthly]
Recruiting NA
Status: Not Yet Recruiting → Recruiting
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Jan 2021 — Mar 2021 [monthly]
Not Yet Recruiting NA
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Feb 2020 — Jan 2021 [monthly]
Not Yet Recruiting NA
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Aug 2019 — Feb 2020 [monthly]
Not Yet Recruiting NA
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Jul 2019 — Aug 2019 [monthly]
Not Yet Recruiting NA
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May 2019 — Jul 2019 [monthly]
Not Yet Recruiting NA
First recorded
Eligibility Summary
This study will explore the effect of ECT treatments plus usual care (ECT+UC) in reducing severe agitation in patients with moderate to severe dementia including Alzheimer's Disease, Vascular dementia, Frontotemporal dementia, and Dementia with Lewy Bodies. The study will also determine the tolerability/safety outcomes of ECT+UC.
Contact Information
- Brent Forester
- Emory University
- Mayo Clinic
- Medical University of South Carolina
- Pine Rest Christian Mental Health Services
- The Zucker Hillside Hospital
For direct contact, visit the study record on ClinicalTrials.gov .