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Completed OBSERVATIONAL NCT03939767

Assessment of Proactive Treatments in Patients With Wet Age-related Macular Degeneration (wAMD) Which Have Never Undergone Treatment of This Particular Disease (XTEND)

Evaluation of an eXtended and proacTive Dosing regimEn in Treatment-Naïve Patients With Wet Age-related Macular Degeneration (wAMD)

Sponsor: Bayer

Conditions Wet Age-related Macular Degeneration
Interventions Aflibercept (Eylea, BAY86-5321)
Updated 54 times since 2019 Last updated: Sep 18, 2024 Started: May 12, 2019 Primary completion: Jul 7, 2023 Completion: Oct 17, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03939767, this observational or N/A phase trial focuses on Wet Age-related Macular Degeneration and remains completed. Sponsored by Bayer, it has been updated 54 times since 2019, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Jul 2024 · 8 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Sep 2025 · 11 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

54 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed

  2. Oct 2024 — Sep 2025 [monthly]

    Completed

  3. Sep 2024 — Oct 2024 [monthly]

    Completed

  4. Jul 2024 — Sep 2024 [monthly]

    Completed

  5. Nov 2023 — Jul 2024 [monthly]

    Completed

    Status: Active Not Recruiting → Completed

▶ Show 49 earlier versions

  1. Oct 2023 — Nov 2023 [monthly]

    Active Not Recruiting

  2. Sep 2023 — Oct 2023 [monthly]

    Active Not Recruiting

  3. Aug 2023 — Sep 2023 [monthly]

    Active Not Recruiting

  4. Jul 2023 — Aug 2023 [monthly]

    Active Not Recruiting

  5. Jun 2023 — Jul 2023 [monthly]

    Active Not Recruiting

  6. May 2023 — Jun 2023 [monthly]

    Active Not Recruiting

  7. Apr 2023 — May 2023 [monthly]

    Active Not Recruiting

  8. Mar 2023 — Apr 2023 [monthly]

    Active Not Recruiting

  9. Feb 2023 — Mar 2023 [monthly]

    Active Not Recruiting

  10. Jan 2023 — Feb 2023 [monthly]

    Active Not Recruiting

  11. Dec 2022 — Jan 2023 [monthly]

    Active Not Recruiting

  12. Nov 2022 — Dec 2022 [monthly]

    Active Not Recruiting

  13. Sep 2022 — Nov 2022 [monthly]

    Active Not Recruiting

  14. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting

  15. Jun 2022 — Jul 2022 [monthly]

    Active Not Recruiting

  16. May 2022 — Jun 2022 [monthly]

    Active Not Recruiting

  17. Apr 2022 — May 2022 [monthly]

    Active Not Recruiting

  18. Mar 2022 — Apr 2022 [monthly]

    Active Not Recruiting

  19. Feb 2022 — Mar 2022 [monthly]

    Active Not Recruiting

  20. Jan 2022 — Feb 2022 [monthly]

    Active Not Recruiting

  21. Dec 2021 — Jan 2022 [monthly]

    Active Not Recruiting

  22. Nov 2021 — Dec 2021 [monthly]

    Active Not Recruiting

  23. Oct 2021 — Nov 2021 [monthly]

    Active Not Recruiting

  24. Sep 2021 — Oct 2021 [monthly]

    Active Not Recruiting

  25. Jun 2021 — Sep 2021 [monthly]

    Active Not Recruiting

  26. May 2021 — Jun 2021 [monthly]

    Active Not Recruiting

  27. Apr 2021 — May 2021 [monthly]

    Active Not Recruiting

  28. Mar 2021 — Apr 2021 [monthly]

    Active Not Recruiting

  29. Feb 2021 — Mar 2021 [monthly]

    Active Not Recruiting

  30. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting

  31. Dec 2020 — Jan 2021 [monthly]

    Active Not Recruiting

  32. Nov 2020 — Dec 2020 [monthly]

    Active Not Recruiting

  33. Oct 2020 — Nov 2020 [monthly]

    Active Not Recruiting

  34. Sep 2020 — Oct 2020 [monthly]

    Active Not Recruiting

  35. Aug 2020 — Sep 2020 [monthly]

    Active Not Recruiting

    Status: Recruiting → Active Not Recruiting

  36. Jul 2020 — Aug 2020 [monthly]

    Recruiting

  37. Jun 2020 — Jul 2020 [monthly]

    Recruiting

  38. May 2020 — Jun 2020 [monthly]

    Recruiting

  39. Apr 2020 — May 2020 [monthly]

    Recruiting

  40. Mar 2020 — Apr 2020 [monthly]

    Recruiting

  41. Feb 2020 — Mar 2020 [monthly]

    Recruiting

  42. Jan 2020 — Feb 2020 [monthly]

    Recruiting

  43. Dec 2019 — Jan 2020 [monthly]

    Recruiting

  44. Nov 2019 — Dec 2019 [monthly]

    Recruiting

  45. Oct 2019 — Nov 2019 [monthly]

    Recruiting

  46. Sep 2019 — Oct 2019 [monthly]

    Recruiting

  47. Aug 2019 — Sep 2019 [monthly]

    Recruiting

  48. Jul 2019 — Aug 2019 [monthly]

    Recruiting

    Status: Not Yet Recruiting → Recruiting

  49. Jun 2019 — Jul 2019 [monthly]

    Not Yet Recruiting

    First recorded

May 2019

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Bayer
Data source: Bayer

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Multiple Locations, Argentina , Multiple Locations, Australia , Multiple Locations, Belgium , Multiple Locations, Canada , Multiple Locations, China , Multiple Locations, Colombia , Multiple Locations, Denmark , Multiple Locations, France , Multiple Locations, Ireland , Multiple Locations, Italy and 7 more locations