Evaluation of Efficacy and Safety of Neoadjuvant Treatment With Pamrevlumab in Combination With Chemotherapy (Either Gemcitabine Plus Nab-paclitaxel or FOLFIRINOX) in Participants With Locally Advanced, Unresectable Pancreatic Cancer (LAPIS)
A Phase 3, Randomized, Double-Blind Study of Pamrevlumab or Placebo in Combination With Either Gemcitabine Plus Nab-paclitaxel or FOLFIRINOX as Neoadjuvant Treatment in Patients With Locally Advanced, Unresectable Pancreatic Cancer
Sponsor: Kyntra Bio
Listed as NCT03941093, this PHASE3 trial focuses on Pancreatic Cancer Non-resectable and remains completed. Sponsored by Kyntra Bio, it has been updated 29 times since 2019, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.
Status Flow
Change History
29 versions recorded-
Feb 2026 — Present [monthly]
Completed PHASE3
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Sep 2025 — Feb 2026 [monthly]
Completed PHASE3
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Dec 2024 — Sep 2025 [monthly]
Completed PHASE3
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Sep 2024 — Dec 2024 [monthly]
Completed PHASE3
Status: Active Not Recruiting → Completed
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Jul 2024 — Sep 2024 [monthly]
Active Not Recruiting PHASE3
▶ Show 24 earlier versions
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Mar 2024 — Jul 2024 [monthly]
Active Not Recruiting PHASE3
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Jan 2023 — Mar 2024 [monthly]
Active Not Recruiting PHASE3
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Sep 2022 — Jan 2023 [monthly]
Active Not Recruiting PHASE3
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Apr 2022 — Sep 2022 [monthly]
Active Not Recruiting PHASE3
Status: Recruiting → Active Not Recruiting
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Oct 2021 — Apr 2022 [monthly]
Recruiting PHASE3
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Sep 2021 — Oct 2021 [monthly]
Recruiting PHASE3
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Mar 2021 — Sep 2021 [monthly]
Recruiting PHASE3
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Jan 2021 — Mar 2021 [monthly]
Recruiting PHASE3
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Dec 2020 — Jan 2021 [monthly]
Recruiting PHASE3
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Nov 2020 — Dec 2020 [monthly]
Recruiting PHASE3
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Sep 2020 — Nov 2020 [monthly]
Recruiting PHASE3
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Aug 2020 — Sep 2020 [monthly]
Recruiting PHASE3
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Jul 2020 — Aug 2020 [monthly]
Recruiting PHASE3
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Jun 2020 — Jul 2020 [monthly]
Recruiting PHASE3
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May 2020 — Jun 2020 [monthly]
Recruiting PHASE3
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Mar 2020 — May 2020 [monthly]
Recruiting PHASE3
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Feb 2020 — Mar 2020 [monthly]
Recruiting PHASE3
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Jan 2020 — Feb 2020 [monthly]
Recruiting PHASE3
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Dec 2019 — Jan 2020 [monthly]
Recruiting PHASE3
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Oct 2019 — Dec 2019 [monthly]
Recruiting PHASE3
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Sep 2019 — Oct 2019 [monthly]
Recruiting PHASE3
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Aug 2019 — Sep 2019 [monthly]
Recruiting PHASE3
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Jul 2019 — Aug 2019 [monthly]
Recruiting PHASE3
Status: Not Yet Recruiting → Recruiting
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Jun 2019 — Jul 2019 [monthly]
Not Yet Recruiting PHASE3
First recorded
May 2019
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
No eligibility information available.
Contact Information
- Kyntra Bio
For direct contact, visit the study record on ClinicalTrials.gov .