Double-Blinded, Placebo-Controlled Phase 1b Study for Safety, PK, Efficacy, PD of RO7049665 in Participants With Ulcerative Colitis (UC)
A Multicenter, Randomized, Double-Blind, Placebo Controlled Phase Ib Study to Investigate the Safety, Tolerability, Pharmacokinetics, Preliminary Efficacy, and Pharmacodynamics of Subcutaneously Administered RO7049665 in Participants With Active Ulcerative Colitis
Sponsor: Hoffmann-La Roche
Terminated
The decision to terminate study WP40161 was based on that treatment with RO7049665 showed trends in efficacy, however these data were below expectations and would not have supported superiority over standard of care.
Other terminated trials from Hoffmann-La Roche
Other Ulcerative Colitis trials with similar outcome
Listed as NCT03943550, this PHASE1 trial focuses on Ulcerative Colitis and remains terminated or withdrawn. Sponsored by Hoffmann-La Roche, it has been updated 19 times since 2019, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.
Status Flow
Change History
19 versions recorded-
Sep 2025 — Present [monthly]
Terminated PHASE1
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Sep 2024 — Sep 2025 [monthly]
Terminated PHASE1
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Jul 2024 — Sep 2024 [monthly]
Terminated PHASE1
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Mar 2024 — Jul 2024 [monthly]
Terminated PHASE1
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Dec 2021 — Mar 2024 [monthly]
Terminated PHASE1
▶ Show 14 earlier versions
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Nov 2021 — Dec 2021 [monthly]
Terminated PHASE1
Status: Recruiting → Terminated
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Oct 2021 — Nov 2021 [monthly]
Recruiting PHASE1
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Sep 2021 — Oct 2021 [monthly]
Recruiting PHASE1
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Jun 2021 — Sep 2021 [monthly]
Recruiting PHASE1
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May 2021 — Jun 2021 [monthly]
Recruiting PHASE1
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Apr 2021 — May 2021 [monthly]
Recruiting PHASE1
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Mar 2021 — Apr 2021 [monthly]
Recruiting PHASE1
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Jan 2021 — Mar 2021 [monthly]
Recruiting PHASE1
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Nov 2020 — Jan 2021 [monthly]
Recruiting PHASE1
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Oct 2020 — Nov 2020 [monthly]
Recruiting PHASE1
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Sep 2020 — Oct 2020 [monthly]
Recruiting PHASE1
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Aug 2020 — Sep 2020 [monthly]
Recruiting PHASE1
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Jul 2020 — Aug 2020 [monthly]
Recruiting PHASE1
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Jun 2019 — Jul 2020 [monthly]
Recruiting PHASE1
First recorded
May 2019
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
No eligibility information available.
Contact Information
- Hoffmann-La Roche
For direct contact, visit the study record on ClinicalTrials.gov .