deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT03950674

Study of Pemetrexed+Platinum Chemotherapy With or Without Pembrolizumab (MK-3475) in Participants With First Line Metastatic Nonsquamous Non-small Cell Lung Cancer (MK-3475-189/KEYNOTE-189)-Japan Extension Study

A Randomized, Double-Blind, Phase III Study of Platinum+Pemetrexed Chemotherapy With or Without Pembrolizumab (MK-3475) in First Line Metastatic Non-squamous Non-small Cell Lung Cancer Subjects (KEYNOTE-189)

Sponsor: Merck Sharp & Dohme LLC

Updated 14 times since 2019 Last updated: May 13, 2024 Started: Feb 22, 2016 Primary completion: May 20, 2019 Completion: Jun 22, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Non-Small-Cell Lung Carcinoma, this trial is completed. The trial is conducted by Merck Sharp & Dohme LLC and has accumulated 14 data snapshots since 2016. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jun 2019 – ~Apr 2020 · 10 months · monthly snapshot~Apr 2020 – ~Jul 2020 · 3 months · monthly snapshot~Jul 2020 – ~Nov 2020 · 4 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Dec 2021 · 11 months · monthly snapshot~Dec 2021 – ~Apr 2022 · 4 months · monthly snapshot~Apr 2022 – ~Jun 2022 · 2 months · monthly snapshot~Jun 2022 – ~Sep 2022 · 3 months · monthly snapshot~Sep 2022 – ~Feb 2023 · 5 months · monthly snapshot~Feb 2023 – ~Jun 2023 · 4 months · monthly snapshot~Jun 2023 – ~Aug 2023 · 2 months · monthly snapshot~Aug 2023 – ~Jul 2024 · 11 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 22 months · monthly snapshot

Change History

14 versions recorded
  1. Sep 2024 — Present [monthly]

    Completed PHASE3

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  3. Aug 2023 — Jul 2024 [monthly]

    Completed PHASE3

    Status: Active Not RecruitingCompleted

  4. Jun 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE3

  5. Feb 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE3

Show 9 earlier versions
  1. Sep 2022 — Feb 2023 [monthly]

    Active Not Recruiting PHASE3

  2. Jun 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE3

  3. Apr 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE3

  4. Dec 2021 — Apr 2022 [monthly]

    Active Not Recruiting PHASE3

  5. Jan 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE3

  6. Nov 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE3

  7. Jul 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE3

  8. Apr 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE3

  9. Jun 2019 — Apr 2020 [monthly]

    Active Not Recruiting PHASE3

    First recorded

Feb 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Merck Sharp & Dohme LLC
Data source: Merck Sharp & Dohme LLC

For direct contact, visit the study record on ClinicalTrials.gov .