deltatrials
Completed PHASE2 INTERVENTIONAL 1-arm NCT03993353

Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer

A Phase II Study of Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Sponsor: University of California, San Diego

Updated 12 times since 2019 Last updated: Jan 26, 2026 Started: Apr 7, 2020 Primary completion: Apr 16, 2022 Completion: Jan 9, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03993353, this PHASE2 trial focuses on Cancer and Cancer of Esophagus and remains completed. Sponsored by University of California, San Diego, it has been updated 12 times since 2020, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jul 2019 – ~Feb 2020 · 7 months · monthly snapshotNot Yet Recruiting~Feb 2020 – ~May 2020 · 3 months · monthly snapshotNot Yet Recruiting~May 2020 – ~Jan 2021 · 8 months · monthly snapshotRecruiting~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshotRecruiting~Sep 2021 – ~Sep 2022 · 12 months · monthly snapshotRecruiting~Sep 2022 – ~Sep 2023 · 12 months · monthly snapshotActive Not Recruiting~Sep 2023 – ~Apr 2024 · 7 months · monthly snapshotActive Not Recruiting~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotRecruiting~Sep 2024 – ~Dec 2024 · 3 months · monthly snapshotRecruiting~Dec 2024 – ~Feb 2026 · 14 months · monthly snapshotActive Not Recruiting~Feb 2026 – present · 5 months · monthly snapshotCompleted

Change History

12 versions recorded
  1. Feb 2026 — Present [monthly]

    Completed PHASE2

    Status: Active Not RecruitingCompleted

  2. Dec 2024 — Feb 2026 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  3. Sep 2024 — Dec 2024 [monthly]

    Recruiting PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  5. Apr 2024 — Jul 2024 [monthly]

    Recruiting PHASE2

    Status: Active Not RecruitingRecruiting

Show 7 earlier versions
  1. Sep 2023 — Apr 2024 [monthly]

    Active Not Recruiting PHASE2

  2. Sep 2022 — Sep 2023 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  3. Sep 2021 — Sep 2022 [monthly]

    Recruiting PHASE2

  4. Jan 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  5. May 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  6. Feb 2020 — May 2020 [monthly]

    Not Yet Recruiting PHASE2

  7. Jul 2019 — Feb 2020 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • University of California, San Diego
Data source: University of California, San Diego

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations