deltatrials
Terminated PHASE1 INTERVENTIONAL 2-arm NCT04000529

Phase Ib Study of TNO155 in Combination With Spartalizumab or Ribociclib in Selected Malignancies

A Phase Ib, Open-label, Multi-center Study to Characterize the Safety, Tolerability, and Preliminary Efficacy of TNO155 in Combination With Spartalizumab or Ribociclib in Selected Malignancies

Sponsor: Novartis Pharmaceuticals

Conditions Colorectal Cancer Esophageal SCC Gastrointestinal Stromal Tumors Head and Neck Squamous Cell Carcinoma Non-small Cell Lung Carcinoma
Interventions Ribociclib Spartalizumab TNO155
Updated 29 times since 2019 Last updated: Sep 24, 2025 Started: Jul 30, 2019 Primary completion: Jan 15, 2024 Completion: Jan 15, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Business reasons

Other terminated trials from Novartis Pharmaceuticals

See all terminations from Novartis Pharmaceuticals

Other Colorectal Cancer trials with similar outcome

Browse all Colorectal Cancer trials

Listed as NCT04000529, this PHASE1 trial focuses on Colorectal Cancer and Esophageal SCC and remains terminated or withdrawn. Sponsored by Novartis Pharmaceuticals, it has been updated 29 times since 2019, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Oct 2019 · 2 months · monthly snapshot~Oct 2019 – ~Mar 2020 · 5 months · monthly snapshot~Mar 2020 – ~May 2020 · 2 months · monthly snapshot~May 2020 – ~Jul 2020 · 2 months · monthly snapshot~Jul 2020 – ~Oct 2020 · 3 months · monthly snapshot~Oct 2020 – ~Dec 2020 · 2 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Jun 2021 · 2 months · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Jan 2022 · 4 months · monthly snapshot~Jan 2022 – ~Mar 2022 · 59 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~Dec 2022 · 8 months · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Apr 2023 · 59 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Oct 2023 · 5 months · monthly snapshot~Oct 2023 – ~Dec 2023 · 2 months · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Jul 2024 · 5 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Dec 2024 · 3 months · monthly snapshot~Dec 2024 – ~Sep 2025 · 9 months · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – present · 9 months · monthly snapshot

Change History

29 versions recorded

  1. Oct 2025 — Present [monthly]

    Terminated PHASE1

  2. Sep 2025 — Oct 2025 [monthly]

    Terminated PHASE1

  3. Dec 2024 — Sep 2025 [monthly]

    Terminated PHASE1

  4. Sep 2024 — Dec 2024 [monthly]

    Terminated PHASE1

  5. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE1

▶ Show 24 earlier versions

  1. Feb 2024 — Jul 2024 [monthly]

    Terminated PHASE1

    Status: Active Not Recruiting → Terminated

  2. Jan 2024 — Feb 2024 [monthly]

    Active Not Recruiting PHASE1

  3. Dec 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE1

  4. Oct 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE1

  5. May 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE1

  6. Apr 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  7. Feb 2023 — Apr 2023 [monthly]

    Recruiting PHASE1

  8. Jan 2023 — Feb 2023 [monthly]

    Recruiting PHASE1

  9. Dec 2022 — Jan 2023 [monthly]

    Recruiting PHASE1

  10. Apr 2022 — Dec 2022 [monthly]

    Recruiting PHASE1

  11. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE1

  12. Jan 2022 — Mar 2022 [monthly]

    Recruiting PHASE1

  13. Sep 2021 — Jan 2022 [monthly]

    Recruiting PHASE1

  14. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  15. Apr 2021 — Jun 2021 [monthly]

    Recruiting PHASE1

  16. Jan 2021 — Apr 2021 [monthly]

    Recruiting PHASE1

  17. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  18. Oct 2020 — Dec 2020 [monthly]

    Recruiting PHASE1

  19. Jul 2020 — Oct 2020 [monthly]

    Recruiting PHASE1

  20. May 2020 — Jul 2020 [monthly]

    Recruiting PHASE1

  21. Mar 2020 — May 2020 [monthly]

    Recruiting PHASE1

  22. Oct 2019 — Mar 2020 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  23. Aug 2019 — Oct 2019 [monthly]

    Not Yet Recruiting PHASE1

  24. Jul 2019 — Aug 2019 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Novartis Pharmaceuticals
Data source: Novartis

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations