Active Not Recruiting PHASE1/PHASE2 INTERVENTIONAL 1-arm NCT04017650

Encorafenib, Cetuximab, and Nivolumab in Treating Patients With Microsatellite Stable, BRAFV600E Mutated Unresectable or Metastatic Colorectal Cancer

Phase I/II Trial of Encorafenib, Cetuximab, and Nivolumab in Microsatellite Stable BRAFV600E Metastatic Colorectal Cancer (BMS-MDACC CA209-8P6/ARRAY IST-818-101X)

Sponsor: M.D. Anderson Cancer Center

Interventions Cetuximab Encorafenib Nivolumab

Updated 18 times since 2019 Last updated: Nov 18, 2025 Started: Jun 14, 2019 Primary completion: Dec 30, 2027 Completion: Dec 30, 2027

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04017650, this PHASE1/PHASE2 trial focuses on BRAF NP_004324.2:p.V600E and Metastatic Colon Adenocarcinoma and remains ongoing. Sponsored by M.D. Anderson Cancer Center, it has been updated 18 times since 2019, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

Change History

18 versions recorded

Dec 2025 — Present [monthly]

Active Not Recruiting PHASE1/PHASE2
Aug 2025 — Dec 2025 [monthly]

Active Not Recruiting PHASE1/PHASE2
May 2025 — Aug 2025 [monthly]

Active Not Recruiting PHASE1/PHASE2
Nov 2024 — May 2025 [monthly]

Active Not Recruiting PHASE1/PHASE2

Status: Recruiting → Active Not Recruiting
Oct 2024 — Nov 2024 [monthly]

Recruiting PHASE1/PHASE2

▶ Show 13 earlier versions

Sep 2024 — Oct 2024 [monthly]

Recruiting PHASE1/PHASE2
Jul 2024 — Sep 2024 [monthly]

Recruiting PHASE1/PHASE2

Phase: PHASE1_PHASE2 → PHASE1/PHASE2
Mar 2024 — Jul 2024 [monthly]

Recruiting PHASE1_PHASE2
Dec 2023 — Mar 2024 [monthly]

Recruiting PHASE1_PHASE2
Nov 2023 — Dec 2023 [monthly]

Recruiting PHASE1_PHASE2
Oct 2023 — Nov 2023 [monthly]

Recruiting PHASE1_PHASE2
Apr 2023 — Oct 2023 [monthly]

Recruiting PHASE1_PHASE2
Sep 2022 — Apr 2023 [monthly]

Recruiting PHASE1_PHASE2
Nov 2021 — Sep 2022 [monthly]

Recruiting PHASE1_PHASE2
Jan 2021 — Nov 2021 [monthly]

Recruiting PHASE1_PHASE2
Nov 2019 — Jan 2021 [monthly]

Recruiting PHASE1_PHASE2
Sep 2019 — Nov 2019 [monthly]

Recruiting PHASE1_PHASE2
Aug 2019 — Sep 2019 [monthly]

Recruiting PHASE1_PHASE2

First recorded

Jun 2019

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Data source: M.D. Anderson Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Houston, United States