deltatrials
Completed PHASE1 INTERVENTIONAL 2-arm NCT04023110

Risk-Guided Cardioprotection With Carvedilol in Breast Cancer Patients Treated With Doxorubicin and/or Trastuzumab (CCTGuide Pilot)

A Pilot Study of Risk-Guided Cardioprotection With Carvedilol in Breast Cancer Patients Treated With Doxorubicin and/or Trastuzumab

Sponsor: Abramson Cancer Center at Penn Medicine

Interventions Carvedilol
Updated 15 times since 2019 Last updated: Sep 23, 2025 Started: Aug 9, 2019 Primary completion: Aug 31, 2024 Completion: Jan 14, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04023110, this PHASE1 trial focuses on Breast Cancer and Cardiomyopathies and remains completed. Sponsored by Abramson Cancer Center at Penn Medicine, it has been updated 15 times since 2019, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Aug 2019 – ~Nov 2019 · 3 months · monthly snapshot~Nov 2019 – ~Nov 2020 · 12 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Jun 2021 · 5 months · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Sep 2022 · 12 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~May 2023 · 6 months · monthly snapshot~May 2023 – ~Nov 2023 · 6 months · monthly snapshot~Nov 2023 – ~Jul 2024 · 8 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Feb 2025 · 3 months · monthly snapshot~Feb 2025 – ~Nov 2025 · 9 months · monthly snapshot~Nov 2025 – present · 8 months · monthly snapshot

Change History

15 versions recorded
  1. Nov 2025 — Present [monthly]

    Completed PHASE1

  2. Feb 2025 — Nov 2025 [monthly]

    Completed PHASE1

    Status: Active Not RecruitingCompleted

  3. Nov 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Sep 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE1

  5. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

Show 10 earlier versions
  1. Nov 2023 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

  2. May 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE1

  3. Nov 2022 — May 2023 [monthly]

    Active Not Recruiting PHASE1

  4. Sep 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE1

    Status: RecruitingActive Not Recruiting

  5. Sep 2021 — Sep 2022 [monthly]

    Recruiting PHASE1

  6. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  7. Jan 2021 — Jun 2021 [monthly]

    Recruiting PHASE1

  8. Nov 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  9. Nov 2019 — Nov 2020 [monthly]

    Recruiting PHASE1

    Status: Not Yet RecruitingRecruiting

  10. Aug 2019 — Nov 2019 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Abramson Cancer Center at Penn Medicine
  • American Heart Association
  • National Heart, Lung, and Blood Institute (NHLBI)
Data source: Abramson Cancer Center at Penn Medicine

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations