deltatrials
Active Not Recruiting PHASE3 INTERVENTIONAL 2-arm NCT04023552

Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With CVD (Lp(a)HORIZON)

A Randomized Double-blind, Placebo-controlled, Multicenter Trial Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With Established Cardiovascular Disease

Sponsor: Novartis Pharmaceuticals

Conditions Cardiovascular Disease and Lipoprotein(a)
Interventions Placebo TQJ230
Updated 47 times since 2019 Last updated: Feb 24, 2026 Started: Dec 12, 2019 Primary completion: Jun 30, 2026 Completion: Jun 30, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Cardiovascular Disease and Lipoprotein(a) and is currently ongoing. Novartis Pharmaceuticals leads this study, which shows 47 recorded versions since 2019 — indicating substantial longitudinal coverage. Heart and vascular conditions benefit from the kind of long-term tracking this trial provides.

Status Flow

~Aug 2019 – ~Dec 2019 · 4 months · monthly snapshot~Dec 2019 – ~Feb 2020 · 2 months · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Sep 2020 · 3 months · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~May 2021 · 2 months · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Sep 2022 · 3 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Apr 2023 · 5 months · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Sep 2023 · 3 months · monthly snapshot~Sep 2023 – ~Dec 2023 · 3 months · monthly snapshot~Dec 2023 – ~Jun 2024 · 6 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Feb 2025 · 4 months · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~Jul 2025 · 3 months · monthly snapshot~Jul 2025 – ~Aug 2025 · 31 days · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Nov 2025 · 2 months · monthly snapshot~Nov 2025 – ~Dec 2025 · 30 days · monthly snapshot~Dec 2025 – ~Jan 2026 · 31 days · monthly snapshot~Jan 2026 – ~Feb 2026 · 31 days · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

47 versions recorded

  1. Feb 2026 — Present [monthly]

    Active Not Recruiting PHASE3

  2. Jan 2026 — Feb 2026 [monthly]

    Active Not Recruiting PHASE3

  3. Dec 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE3

  4. Nov 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Sep 2025 — Nov 2025 [monthly]

    Active Not Recruiting PHASE3

▶ Show 42 earlier versions

  1. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE3

  2. Jul 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE3

  3. Apr 2025 — Jul 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Mar 2025 — Apr 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Feb 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE3

  6. Oct 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE3

  7. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE3

  8. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

  9. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

  10. Dec 2023 — Jun 2024 [monthly]

    Active Not Recruiting PHASE3

  11. Sep 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE3

  12. Jun 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE3

  13. May 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE3

  14. Apr 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE3

  15. Nov 2022 — Apr 2023 [monthly]

    Active Not Recruiting PHASE3

  16. Sep 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE3

  17. Jun 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  18. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE3

  19. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE3

  20. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE3

  21. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE3

  22. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE3

  23. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE3

  24. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE3

  25. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE3

  26. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE3

  27. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE3

  28. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE3

  29. Mar 2021 — May 2021 [monthly]

    Recruiting PHASE3

  30. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE3

  31. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE3

  32. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE3

  33. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE3

  34. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE3

  35. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE3

  36. Jun 2020 — Sep 2020 [monthly]

    Recruiting PHASE3

  37. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE3

  38. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE3

  39. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE3

  40. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE3

    Status: Not Yet Recruiting → Recruiting

  41. Dec 2019 — Feb 2020 [monthly]

    Not Yet Recruiting PHASE3

  42. Aug 2019 — Dec 2019 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Novartis Pharmaceuticals
Data source: Novartis

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

A Coruña, Spain , Aachen, Germany , Aalst, Belgium , Aarhus N, Denmark , Aguascalientes, Mexico , Ahmedabad, India , Akron, United States , Albany, United States , Alexandria, United States , Alkmaar, Netherlands and 587 more locations