deltatrials
Completed PHASE2 INTERVENTIONAL 2-arm NCT04032626

MCLENA-1: A Clinical Trial for the Assessment of Lenalidomide in Amnestic MCI Patients (MCLENA-1)

MCLENA-1: A Phase II Clinical Trial for the Assessment of Safety, Tolerability, and Efficacy of Lenalidomide in Patients With Mild Cognitive Impairment Due to Alzheimer's Disease

Sponsor: National Institute on Aging (NIA)

Conditions Amyloid Plaque Cognitive Dysfunction Cognitive Impairment, Mild Inflammation, Brain Neurodegeneration
Interventions Lenalidomide 10 mg Placebo
Updated 14 times since 2019 Last updated: Jun 10, 2025 Started: Jul 22, 2020 Primary completion: May 31, 2025 Completion: May 31, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04032626, this PHASE2 trial focuses on Amyloid Plaque and Cognitive Dysfunction and remains completed. Sponsored by National Institute on Aging (NIA), it has been updated 14 times since 2020, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Aug 2019 – ~Dec 2019 · 4 months · monthly snapshot~Dec 2019 – ~Feb 2020 · 2 months · monthly snapshot~Feb 2020 – ~Apr 2020 · 2 months · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Aug 2020 · 3 months · monthly snapshot~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Jun 2021 · 5 months · monthly snapshot~Jun 2021 – ~May 2022 · 11 months · monthly snapshot~May 2022 – ~May 2024 · 24 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jul 2025 · 10 months · monthly snapshot~Jul 2025 – present · 12 months · monthly snapshot

Change History

14 versions recorded

  1. Jul 2025 — Present [monthly]

    Completed PHASE2

    Status: Recruiting → Completed

  2. Sep 2024 — Jul 2025 [monthly]

    Recruiting PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  4. May 2024 — Jul 2024 [monthly]

    Recruiting PHASE2

  5. May 2022 — May 2024 [monthly]

    Recruiting PHASE2

▶ Show 9 earlier versions

  1. Jun 2021 — May 2022 [monthly]

    Recruiting PHASE2

  2. Jan 2021 — Jun 2021 [monthly]

    Recruiting PHASE2

  3. Oct 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  4. Aug 2020 — Oct 2020 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  5. May 2020 — Aug 2020 [monthly]

    Not Yet Recruiting PHASE2

  6. Apr 2020 — May 2020 [monthly]

    Not Yet Recruiting PHASE2

  7. Feb 2020 — Apr 2020 [monthly]

    Not Yet Recruiting PHASE2

  8. Dec 2019 — Feb 2020 [monthly]

    Not Yet Recruiting PHASE2

  9. Aug 2019 — Dec 2019 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Institute on Aging (NIA)
  • St. Joseph's Hospital and Medical Center, Phoenix
  • The Cleveland Clinic
Data source: St. Joseph's Hospital and Medical Center, Phoenix

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations