deltatrials
Unknown NA INTERVENTIONAL 2-arm NCT04048434

Extracorporeal Cytokine Adsorption as Additive Treatment of CAR-T Associated Cytokine Release Syndrome (CRS) (CYTORELEASE)

Effectivity of Extracorporeal Cytokine Adsorption (Cytosorb) as Additive Treatment of CAR-T Cell Associated Cytokine Release (CRS) Syndrome and Encephalopathy Syndrome (CRES)

Sponsor: CytoSorbents, Inc

Interventions Cytosorb
Updated 8 times since 2019 Last updated: Mar 26, 2021 Started: Jun 30, 2021 Primary completion: Sep 30, 2023 Completion: Sep 30, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This NA trial investigates CAR-T and Cytokine Release Syndrome and is currently ongoing. CytoSorbents, Inc leads this study, which shows 8 recorded versions since 2021 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Sep 2019 – ~Feb 2020 · 5 months · monthly snapshotNot Yet Recruiting~Feb 2020 – ~Jan 2021 · 11 months · monthly snapshotNot Yet Recruiting~Jan 2021 – ~May 2021 · 4 months · monthly snapshotNot Yet Recruiting~May 2021 – ~Jul 2024 · 38 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotRecruiting~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshotRecruiting~Oct 2024 – ~Sep 2025 · 11 months · monthly snapshotUnknown~Sep 2025 – present · 10 months · monthly snapshotUnknown

Change History

8 versions recorded
  1. Sep 2025 — Present [monthly]

    Unknown NA

  2. Oct 2024 — Sep 2025 [monthly]

    Unknown NA

    Status: RecruitingUnknown

  3. Sep 2024 — Oct 2024 [monthly]

    Recruiting NA

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting NA

  5. May 2021 — Jul 2024 [monthly]

    Recruiting NA

    Status: Not Yet RecruitingRecruiting

Show 3 earlier versions
  1. Jan 2021 — May 2021 [monthly]

    Not Yet Recruiting NA

  2. Feb 2020 — Jan 2021 [monthly]

    Not Yet Recruiting NA

  3. Sep 2019 — Feb 2020 [monthly]

    Not Yet Recruiting NA

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • CytoSorbents, Inc
  • Hannover Medical School
Data source: Hannover Medical School

For direct contact, visit the study record on ClinicalTrials.gov .