deltatrials
Active Not Recruiting PHASE1/PHASE2 INTERVENTIONAL 3-arm NCT04077723

A Study to Evaluate the Safety, Pharmacokinetics and Preliminary Anti-Tumor Activity of Englumafusp Alfa in Combination With Obinutuzumab and in Combination With Glofitamab Following a Pre-Treatment Dose of Obinutuzumab in Participants With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma

An Open-Label, Phase I/II Study to Evaluate the Safety, Pharmacokinetics and Preliminary Anti-Tumor Activity of Englumafusp Alfa (RO7227166, A CD19 Targeted 4-1BB Ligand) in Combination With Obinutuzumab and in Combination With Glofitamab Following a Pre-treatment Dose of Obinutuzumab Administered in Participants With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma

Sponsor: Hoffmann-La Roche

Conditions Lymphoma, Non-Hodgkin
Interventions Englumafusp alfa Glofitamab Obinutuzumab Tocilizumab
Updated 67 times since 2019 Last updated: Feb 27, 2026 Started: Aug 13, 2019 Primary completion: Mar 31, 2027 Completion: Mar 31, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1/PHASE2 trial investigates Lymphoma, Non-Hodgkin and is currently ongoing. Hoffmann-La Roche leads this study, which shows 67 recorded versions since 2019 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Apr 2023 · 59 days · monthly snapshot~Apr 2023 – ~Jun 2023 · 2 months · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Apr 2024 · 2 months · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Jul 2025 · 30 days · monthly snapshot~Jul 2025 – ~Aug 2025 · 31 days · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Nov 2025 · 31 days · monthly snapshot~Nov 2025 – ~Dec 2025 · 30 days · monthly snapshot~Dec 2025 – ~Jan 2026 · 31 days · monthly snapshot~Jan 2026 – ~Feb 2026 · 31 days · monthly snapshot~Feb 2026 – ~Mar 2026 · 28 days · monthly snapshot~Mar 2026 – present · 6 months · monthly snapshot

Change History

67 versions recorded

  1. Mar 2026 — Present [monthly]

    Active Not Recruiting PHASE1/PHASE2

    Status: Recruiting → Active Not Recruiting

  2. Feb 2026 — Mar 2026 [monthly]

    Recruiting PHASE1/PHASE2

  3. Jan 2026 — Feb 2026 [monthly]

    Recruiting PHASE1/PHASE2

  4. Dec 2025 — Jan 2026 [monthly]

    Recruiting PHASE1/PHASE2

  5. Nov 2025 — Dec 2025 [monthly]

    Recruiting PHASE1/PHASE2

▶ Show 62 earlier versions

  1. Oct 2025 — Nov 2025 [monthly]

    Recruiting PHASE1/PHASE2

  2. Sep 2025 — Oct 2025 [monthly]

    Recruiting PHASE1/PHASE2

  3. Aug 2025 — Sep 2025 [monthly]

    Recruiting PHASE1/PHASE2

  4. Jul 2025 — Aug 2025 [monthly]

    Recruiting PHASE1/PHASE2

  5. Jun 2025 — Jul 2025 [monthly]

    Recruiting PHASE1/PHASE2

  6. May 2025 — Jun 2025 [monthly]

    Recruiting PHASE1/PHASE2

  7. Apr 2025 — May 2025 [monthly]

    Recruiting PHASE1/PHASE2

  8. Mar 2025 — Apr 2025 [monthly]

    Recruiting PHASE1/PHASE2

  9. Feb 2025 — Mar 2025 [monthly]

    Recruiting PHASE1/PHASE2

  10. Sep 2024 — Feb 2025 [monthly]

    Recruiting PHASE1/PHASE2

    Phase: PHASE1 → PHASE1/PHASE2

  11. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE1

  12. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE1

  13. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE1

  14. May 2024 — Jun 2024 [monthly]

    Recruiting PHASE1

  15. Apr 2024 — May 2024 [monthly]

    Recruiting PHASE1

  16. Feb 2024 — Apr 2024 [monthly]

    Recruiting PHASE1

  17. Jan 2024 — Feb 2024 [monthly]

    Recruiting PHASE1

  18. Dec 2023 — Jan 2024 [monthly]

    Recruiting PHASE1

  19. Nov 2023 — Dec 2023 [monthly]

    Recruiting PHASE1

  20. Oct 2023 — Nov 2023 [monthly]

    Recruiting PHASE1

  21. Sep 2023 — Oct 2023 [monthly]

    Recruiting PHASE1

  22. Aug 2023 — Sep 2023 [monthly]

    Recruiting PHASE1

  23. Jul 2023 — Aug 2023 [monthly]

    Recruiting PHASE1

  24. Jun 2023 — Jul 2023 [monthly]

    Recruiting PHASE1

  25. Apr 2023 — Jun 2023 [monthly]

    Recruiting PHASE1

  26. Feb 2023 — Apr 2023 [monthly]

    Recruiting PHASE1

  27. Jan 2023 — Feb 2023 [monthly]

    Recruiting PHASE1

  28. Dec 2022 — Jan 2023 [monthly]

    Recruiting PHASE1

  29. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE1

  30. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE1

  31. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE1

  32. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE1

  33. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE1

  34. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE1

  35. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE1

  36. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE1

  37. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE1

  38. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE1

  39. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE1

  40. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE1

  41. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE1

  42. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  43. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE1

  44. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE1

  45. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE1

  46. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE1

  47. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE1

  48. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  49. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE1

  50. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE1

  51. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE1

  52. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE1

  53. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE1

  54. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE1

  55. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE1

  56. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE1

  57. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE1

  58. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE1

  59. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE1

  60. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE1

  61. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  62. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE1

    First recorded

Aug 2019

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Hoffmann-La Roche
Data source: Hoffmann-La Roche

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aarhus N, Denmark , Auckland, New Zealand , Austin, United States , Barcelona, Spain , Beijing, China , Bergamo, Italy , Boston, United States , Busan, South Korea , Columbus, United States , Denver, United States and 30 more locations