deltatrials
Recruiting PHASE1/PHASE2 INTERVENTIONAL 2-arm NCT04086485

Lu-177-DOTATATE (Lutathera) in Combination With Olaparib in Inoperable Gastroenteropancreatico Neuroendocrine Tumors (GEP-NET)

Phase I/II Study of Lu-177-DOTATATE (Lutathera) in Combination With Olaparib in Inoperable Gastroenteropancreatico Neuroendocrine Tumors (GEP-NET)

Sponsor: National Cancer Institute (NCI)

Conditions Gastroenteropancreatico Tumors Neuroendocrine Neoplasms Neuroendocrine Tumors
Interventions Amino Acid infusion FDG-PET scanning Ga dotatate scanning Lu-177-DOTATATE Olaparib
Updated 64 times since 2019 Last updated: Dec 16, 2025 Started: Oct 3, 2022 Primary completion: Jul 1, 2027 Completion: Jan 1, 2028
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04086485, this PHASE1/PHASE2 trial focuses on Gastroenteropancreatico Tumors and Neuroendocrine Neoplasms and remains actively recruiting participants. Sponsored by National Cancer Institute (NCI), it has been updated 64 times since 2022, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Oct 2022 · 30 days · monthly snapshot~Oct 2022 – ~Nov 2022 · 31 days · monthly snapshot~Nov 2022 – ~Feb 2023 · 3 months · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Oct 2023 · 3 months · monthly snapshot~Oct 2023 – ~Feb 2024 · 4 months · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~May 2024 · 2 months · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Dec 2024 · 2 months · monthly snapshot~Dec 2024 – ~Jan 2025 · 31 days · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Jul 2025 · 30 days · monthly snapshot~Jul 2025 – ~Aug 2025 · 31 days · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Nov 2025 · 31 days · monthly snapshot~Nov 2025 – ~Dec 2025 · 30 days · monthly snapshot~Dec 2025 – ~Jan 2026 · 31 days · monthly snapshot~Jan 2026 – present · 8 months · monthly snapshot

Change History

64 versions recorded

  1. Jan 2026 — Present [monthly]

    Recruiting PHASE1/PHASE2

  2. Dec 2025 — Jan 2026 [monthly]

    Recruiting PHASE1/PHASE2

  3. Nov 2025 — Dec 2025 [monthly]

    Recruiting PHASE1/PHASE2

  4. Oct 2025 — Nov 2025 [monthly]

    Recruiting PHASE1/PHASE2

  5. Sep 2025 — Oct 2025 [monthly]

    Recruiting PHASE1/PHASE2

▶ Show 59 earlier versions

  1. Aug 2025 — Sep 2025 [monthly]

    Recruiting PHASE1/PHASE2

  2. Jul 2025 — Aug 2025 [monthly]

    Recruiting PHASE1/PHASE2

  3. Jun 2025 — Jul 2025 [monthly]

    Recruiting PHASE1/PHASE2

  4. May 2025 — Jun 2025 [monthly]

    Recruiting PHASE1/PHASE2

  5. Apr 2025 — May 2025 [monthly]

    Recruiting PHASE1/PHASE2

  6. Mar 2025 — Apr 2025 [monthly]

    Recruiting PHASE1/PHASE2

  7. Feb 2025 — Mar 2025 [monthly]

    Recruiting PHASE1/PHASE2

  8. Jan 2025 — Feb 2025 [monthly]

    Recruiting PHASE1/PHASE2

  9. Dec 2024 — Jan 2025 [monthly]

    Recruiting PHASE1/PHASE2

  10. Oct 2024 — Dec 2024 [monthly]

    Recruiting PHASE1/PHASE2

  11. Sep 2024 — Oct 2024 [monthly]

    Recruiting PHASE1/PHASE2

  12. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE1/PHASE2

  13. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  14. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE1_PHASE2

  15. May 2024 — Jun 2024 [monthly]

    Recruiting PHASE1_PHASE2

  16. Mar 2024 — May 2024 [monthly]

    Recruiting PHASE1_PHASE2

  17. Feb 2024 — Mar 2024 [monthly]

    Recruiting PHASE1_PHASE2

  18. Oct 2023 — Feb 2024 [monthly]

    Recruiting PHASE1_PHASE2

  19. Jul 2023 — Oct 2023 [monthly]

    Recruiting PHASE1_PHASE2

  20. Jun 2023 — Jul 2023 [monthly]

    Recruiting PHASE1_PHASE2

  21. May 2023 — Jun 2023 [monthly]

    Recruiting PHASE1_PHASE2

  22. Apr 2023 — May 2023 [monthly]

    Recruiting PHASE1_PHASE2

  23. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE1_PHASE2

  24. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE1_PHASE2

  25. Nov 2022 — Feb 2023 [monthly]

    Recruiting PHASE1_PHASE2

  26. Oct 2022 — Nov 2022 [monthly]

    Recruiting PHASE1_PHASE2

  27. Sep 2022 — Oct 2022 [monthly]

    Recruiting PHASE1_PHASE2

    Status: Not Yet Recruiting → Recruiting

  28. Jul 2022 — Sep 2022 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  29. Jun 2022 — Jul 2022 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  30. May 2022 — Jun 2022 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  31. Apr 2022 — May 2022 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  32. Mar 2022 — Apr 2022 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  33. Feb 2022 — Mar 2022 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  34. Jan 2022 — Feb 2022 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  35. Dec 2021 — Jan 2022 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  36. Nov 2021 — Dec 2021 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  37. Oct 2021 — Nov 2021 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  38. Sep 2021 — Oct 2021 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  39. Jun 2021 — Sep 2021 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  40. May 2021 — Jun 2021 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  41. Apr 2021 — May 2021 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  42. Mar 2021 — Apr 2021 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  43. Feb 2021 — Mar 2021 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  44. Jan 2021 — Feb 2021 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  45. Dec 2020 — Jan 2021 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  46. Nov 2020 — Dec 2020 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  47. Oct 2020 — Nov 2020 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  48. Sep 2020 — Oct 2020 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  49. Aug 2020 — Sep 2020 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  50. Jul 2020 — Aug 2020 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  51. Jun 2020 — Jul 2020 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  52. May 2020 — Jun 2020 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  53. Apr 2020 — May 2020 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  54. Mar 2020 — Apr 2020 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  55. Feb 2020 — Mar 2020 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  56. Jan 2020 — Feb 2020 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  57. Dec 2019 — Jan 2020 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  58. Nov 2019 — Dec 2019 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  59. Oct 2019 — Nov 2019 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Institutes of Health Clinical Center (CC)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations