deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 3-arm NCT04111172

A Vaccine (Ad5.F35-hGCC-PADRE) for the Treatment of Gastrointestinal Adenocarcinoma

A Phase 2A, Dose-Finding Study of Ad5.F35-hGCC-PADRE Vaccine in Adults With Gastrointestinal Adenocarcinomas at Risk of Relapse Post Definitive Surgery and Standard Therapy

Sponsor: Thomas Jefferson University

Conditions Clinical Stage II Gastric Cancer AJCC v8 Clinical Stage IIA Gastric Cancer AJCC v8 Clinical Stage IIB Esophageal Adenocarcinoma AJCC v8 Clinical Stage IIB Gastric Cancer AJCC v8 Clinical Stage III Esophageal Adenocarcinoma AJCC v8 Clinical Stage III Gastric Cancer AJCC v8 Colorectal Adenocarcinoma Gastric Adenocarcinoma Malignant Digestive System Neoplasm Malignant Solid Neoplasm Pancreatic Ductal Adenocarcinoma Pathologic Stage II Gastric Cancer AJCC v8 Pathologic Stage IIB Esophageal Adenocarcinoma AJCC v8 Pathologic Stage IIB Gastric Cancer AJCC v8 Pathologic Stage III Esophageal Adenocarcinoma AJCC v8 Pathologic Stage III Gastric Cancer AJCC v8 Pathologic Stage IIIA Esophageal Adenocarcinoma AJCC v8 Pathologic Stage IIIA Gastric Cancer AJCC v8 Pathologic Stage IIIB Esophageal Adenocarcinoma AJCC v8 Pathologic Stage IIIB Gastric Cancer AJCC v8 Pathologic Stage IIIC Gastric Cancer AJCC v8 Small Intestinal Adenocarcinoma Stage I Pancreatic Cancer AJCC v8 Stage IA Pancreatic Cancer AJCC v8 Stage IB Pancreatic Cancer AJCC v8 Stage II Pancreatic Cancer AJCC v8 Stage IIA Pancreatic Cancer AJCC v8 Stage IIB Pancreatic Cancer AJCC v8 Stage III Colorectal Cancer AJCC v8 Stage III Pancreatic Cancer AJCC v8 Stage III Small Intestinal Adenocarcinoma AJCC v8 Stage IIIA Colorectal Cancer AJCC v8 Stage IIIA Small Intestinal Adenocarcinoma AJCC v8 Stage IIIB Colorectal Cancer AJCC v8 Stage IIIC Colorectal Cancer AJCC v8 Stage IV Colorectal Cancer AJCC v8 Stage IVA Colorectal Cancer AJCC v8 Stage IVB Colorectal Cancer AJCC v8
Updated 15 times since 2019 Last updated: Aug 20, 2025 Started: Nov 10, 2020 Primary completion: Mar 1, 2026 Completion: Mar 1, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04111172, this PHASE2 trial focuses on Clinical Stage II Gastric Cancer AJCC v8 and Clinical Stage IIA Gastric Cancer AJCC v8 and remains ongoing. Sponsored by Thomas Jefferson University, it has been updated 15 times since 2020, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Nov 2019 – ~Feb 2020 · 3 months · monthly snapshot~Feb 2020 – ~Jun 2020 · 4 months · monthly snapshot~Jun 2020 – ~Dec 2020 · 6 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Dec 2021 · 3 months · monthly snapshot~Dec 2021 – ~Dec 2022 · 12 months · monthly snapshot~Dec 2022 – ~Dec 2023 · 12 months · monthly snapshot~Dec 2023 – ~Feb 2024 · 2 months · monthly snapshot~Feb 2024 – ~Jun 2024 · 4 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – ~Sep 2025 · 7 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

15 versions recorded
  1. Sep 2025 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Feb 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE2

    Status: SuspendedActive Not Recruiting

  3. Sep 2024 — Feb 2025 [monthly]

    Suspended PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Suspended PHASE2

  5. Jun 2024 — Jul 2024 [monthly]

    Suspended PHASE2

Show 10 earlier versions
  1. Feb 2024 — Jun 2024 [monthly]

    Suspended PHASE2

    Status: RecruitingSuspended

  2. Dec 2023 — Feb 2024 [monthly]

    Recruiting PHASE2

  3. Dec 2022 — Dec 2023 [monthly]

    Recruiting PHASE2

  4. Dec 2021 — Dec 2022 [monthly]

    Recruiting PHASE2

  5. Sep 2021 — Dec 2021 [monthly]

    Recruiting PHASE2

  6. Jan 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  7. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  8. Jun 2020 — Dec 2020 [monthly]

    Not Yet Recruiting PHASE2

  9. Feb 2020 — Jun 2020 [monthly]

    Not Yet Recruiting PHASE2

  10. Nov 2019 — Feb 2020 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Thomas Jefferson University
Data source: Thomas Jefferson University

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations