deltatrials
Recruiting PHASE2 INTERVENTIONAL 2-arm NCT04141020

Effect of Sirolimus on Molecular Alterations in Cerebral Aneurysms

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Conditions Cerebral Aneurysm
Interventions Endovascular treatment Microsurgical clipping Sirolimus
Updated 22 times since 2019 Last updated: Mar 14, 2025 Started: Oct 27, 2021 Primary completion: Nov 1, 2026 Completion: Nov 1, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Cerebral Aneurysm and is currently actively recruiting participants. National Institute of Neurological Disorders and Stroke (NINDS) leads this study, which shows 22 recorded versions since 2021 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Nov 2019 – ~Feb 2020 · 3 months · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Aug 2020 · 2 months · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Dec 2020 · 2 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Apr 2021 · 59 days · monthly snapshot~Apr 2021 – ~Jun 2021 · 2 months · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Dec 2021 · 3 months · monthly snapshot~Dec 2021 – ~Sep 2022 · 9 months · monthly snapshot~Sep 2022 – ~Sep 2023 · 12 months · monthly snapshot~Sep 2023 – ~Jul 2024 · 10 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Apr 2025 · 7 months · monthly snapshot~Apr 2025 – present · 15 months · monthly snapshot

Change History

22 versions recorded

  1. Apr 2025 — Present [monthly]

    Recruiting PHASE2

  2. Sep 2024 — Apr 2025 [monthly]

    Recruiting PHASE2

  3. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  4. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE2

  5. Sep 2023 — Jul 2024 [monthly]

    Recruiting PHASE2

▶ Show 17 earlier versions

  1. Sep 2022 — Sep 2023 [monthly]

    Recruiting PHASE2

  2. Dec 2021 — Sep 2022 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  3. Sep 2021 — Dec 2021 [monthly]

    Not Yet Recruiting PHASE2

  4. Jun 2021 — Sep 2021 [monthly]

    Not Yet Recruiting PHASE2

  5. Apr 2021 — Jun 2021 [monthly]

    Not Yet Recruiting PHASE2

  6. Feb 2021 — Apr 2021 [monthly]

    Not Yet Recruiting PHASE2

  7. Jan 2021 — Feb 2021 [monthly]

    Not Yet Recruiting PHASE2

  8. Dec 2020 — Jan 2021 [monthly]

    Not Yet Recruiting PHASE2

  9. Oct 2020 — Dec 2020 [monthly]

    Not Yet Recruiting PHASE2

  10. Sep 2020 — Oct 2020 [monthly]

    Not Yet Recruiting PHASE2

  11. Aug 2020 — Sep 2020 [monthly]

    Not Yet Recruiting PHASE2

  12. Jun 2020 — Aug 2020 [monthly]

    Not Yet Recruiting PHASE2

  13. May 2020 — Jun 2020 [monthly]

    Not Yet Recruiting PHASE2

  14. Apr 2020 — May 2020 [monthly]

    Not Yet Recruiting PHASE2

  15. Mar 2020 — Apr 2020 [monthly]

    Not Yet Recruiting PHASE2

  16. Feb 2020 — Mar 2020 [monthly]

    Not Yet Recruiting PHASE2

  17. Nov 2019 — Feb 2020 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Institute of Neurological Disorders and Stroke (NINDS)
  • University of Miami
Data source: University of Miami

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations