deltatrials
Completed PHASE2 INTERVENTIONAL 2-arm NCT04144517

A Study of ALKS 4230 (Nemvaleukin Alfa) With Pembrolizumab in Head and Neck Cancer

A Phase 2 Study of ALKS 4230 in Combination With Anti-PD-1 (Pembrolizumab) in Patients With Advanced or Recurrent Head and Neck Squamous Cell Cancer Currently on Treatment With Anti-PD-(L)1 Without Having Achieved a Complete Remission

Sponsor: Immune Oncology Network (ION)

Updated 14 times since 2019 Last updated: Sep 24, 2024 Started: Feb 5, 2020 Primary completion: Oct 8, 2021 Completion: Jan 7, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04144517, this PHASE2 trial focuses on Squamous Cell Carcinoma of Head and Neck and remains completed. Sponsored by Immune Oncology Network (ION), it has been updated 14 times since 2020, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Nov 2019 – ~Feb 2020 · 3 months · monthly snapshot~Feb 2020 – ~Apr 2020 · 2 months · monthly snapshot~Apr 2020 – ~Sep 2020 · 5 months · monthly snapshot~Sep 2020 – ~Jan 2021 · 4 months · monthly snapshot~Jan 2021 – ~May 2021 · 4 months · monthly snapshot~May 2021 – ~Oct 2021 · 5 months · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Sep 2022 · 10 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Feb 2024 · 14 months · monthly snapshot~Feb 2024 – ~Jul 2024 · 5 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – present · 20 months · monthly snapshot

Change History

14 versions recorded
  1. Nov 2024 — Present [monthly]

    Completed PHASE2

  2. Sep 2024 — Nov 2024 [monthly]

    Completed PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  4. Feb 2024 — Jul 2024 [monthly]

    Completed PHASE2

  5. Dec 2022 — Feb 2024 [monthly]

    Completed PHASE2

    Status: Active Not RecruitingCompleted

Show 9 earlier versions
  1. Sep 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE2

  2. Nov 2021 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

  3. Oct 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE2

  4. May 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  5. Jan 2021 — May 2021 [monthly]

    Recruiting PHASE2

  6. Sep 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  7. Apr 2020 — Sep 2020 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  8. Feb 2020 — Apr 2020 [monthly]

    Not Yet Recruiting PHASE2

  9. Nov 2019 — Feb 2020 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Immune Oncology Network (ION)
  • Mural Oncology, Inc
Data source: Mural Oncology, Inc

For direct contact, visit the study record on ClinicalTrials.gov .