Active Not Recruiting PHASE1/PHASE2 INTERVENTIONAL 1-arm NCT04151082

High Dose Steroid Therapy (Prednisone or Methylprednisolone) for the Improvement of Symptoms of Late Radiation-Associated Lower Cranial Neuropathy in Oropharyngeal Cancer Survivors

Stop LCNP: High Dose Steroid Therapy for Late Radiation-Associated Lower Cranial Neuropathy: A Phase I/II Dose Finding Trial and Data Registry

Sponsor: M.D. Anderson Cancer Center

Conditions Cranial Nerve Disorder Head and Neck Carcinoma Oropharyngeal Carcinoma

Interventions Methylprednisolone Prednisone Quality-of-Life Assessment Questionnaire Administration

Updated 18 times since 2019 Last updated: Jan 12, 2026 Started: Oct 16, 2019 Primary completion: Jul 31, 2027 Completion: Jul 31, 2027

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1/PHASE2 trial investigates Cranial Nerve Disorder and Head and Neck Carcinoma and is currently ongoing. M.D. Anderson Cancer Center leads this study, which shows 18 recorded versions since 2019 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

Change History

18 versions recorded

Feb 2026 — Present [monthly]

Active Not Recruiting PHASE1/PHASE2
Aug 2025 — Feb 2026 [monthly]

Active Not Recruiting PHASE1/PHASE2
May 2025 — Aug 2025 [monthly]

Active Not Recruiting PHASE1/PHASE2

Status: Recruiting → Active Not Recruiting
Dec 2024 — May 2025 [monthly]

Recruiting PHASE1/PHASE2
Sep 2024 — Dec 2024 [monthly]

Recruiting PHASE1/PHASE2

▶ Show 13 earlier versions

Jul 2024 — Sep 2024 [monthly]

Recruiting PHASE1/PHASE2

Phase: PHASE1_PHASE2 → PHASE1/PHASE2
Jun 2024 — Jul 2024 [monthly]

Recruiting PHASE1_PHASE2
May 2024 — Jun 2024 [monthly]

Recruiting PHASE1_PHASE2

Status: Active Not Recruiting → Recruiting
Jan 2024 — May 2024 [monthly]

Active Not Recruiting PHASE1_PHASE2

Status: Recruiting → Active Not Recruiting
Sep 2023 — Jan 2024 [monthly]

Recruiting PHASE1_PHASE2
Dec 2022 — Sep 2023 [monthly]

Recruiting PHASE1_PHASE2
Jun 2022 — Dec 2022 [monthly]

Recruiting PHASE1_PHASE2
May 2022 — Jun 2022 [monthly]

Recruiting PHASE1_PHASE2
Jan 2021 — May 2022 [monthly]

Recruiting PHASE1_PHASE2
Dec 2020 — Jan 2021 [monthly]

Recruiting PHASE1_PHASE2
Mar 2020 — Dec 2020 [monthly]

Recruiting PHASE1_PHASE2
Feb 2020 — Mar 2020 [monthly]

Recruiting PHASE1_PHASE2
Dec 2019 — Feb 2020 [monthly]

Recruiting PHASE1_PHASE2

First recorded

Oct 2019

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Data source: M.D. Anderson Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Houston, United States