deltatrials
Active Not Recruiting OBSERVATIONAL NCT04157322

Plasma 5hmC Signatures as a Marker of Colorectal / Appendiceal Peritoneal Metastasis

5-hydroxymethylation Signatures in Plasma Circulating Cell-free DNA as Markers for Tumor Burden and Recurrence in Appendiceal and Colorectal Peritoneal Metastasis

Sponsor: University of Chicago

Conditions Appendix Cancer Colorectal Cancer Metastatic Colorectal Cancer Stage IV Colorectal Cancer, Genetics of
Interventions prospective single arm biomarker (plasma cell-free DNA hydroxymethylation) study
Updated 9 times since 2019 Last updated: Dec 2, 2025 Started: Aug 26, 2019 Primary completion: Oct 31, 2027 Completion: Oct 31, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This observational or N/A phase trial investigates Appendix Cancer and Colorectal Cancer Metastatic and is currently ongoing. University of Chicago leads this study, which shows 9 recorded versions since 2019 — indicating limited longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Dec 2019 – ~Nov 2020 · 11 months · monthly snapshotRecruiting~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshotRecruiting~Jan 2021 – ~Dec 2021 · 11 months · monthly snapshotRecruiting~Dec 2021 – ~Mar 2024 · 27 months · monthly snapshotRecruiting~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshotActive Not Recruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotActive Not Recruiting~Sep 2024 – ~Apr 2025 · 7 months · monthly snapshotActive Not Recruiting~Apr 2025 – ~Jan 2026 · 9 months · monthly snapshotActive Not Recruiting~Jan 2026 – present · 6 months · monthly snapshotActive Not Recruiting

Change History

9 versions recorded

  1. Jan 2026 — Present [monthly]

    Active Not Recruiting

  2. Apr 2025 — Jan 2026 [monthly]

    Active Not Recruiting

  3. Sep 2024 — Apr 2025 [monthly]

    Active Not Recruiting

  4. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting

  5. Mar 2024 — Jul 2024 [monthly]

    Active Not Recruiting

    Status: Recruiting → Active Not Recruiting

▶ Show 4 earlier versions

  1. Dec 2021 — Mar 2024 [monthly]

    Recruiting

  2. Jan 2021 — Dec 2021 [monthly]

    Recruiting

  3. Nov 2020 — Jan 2021 [monthly]

    Recruiting

  4. Dec 2019 — Nov 2020 [monthly]

    Recruiting

    First recorded

Aug 2019

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • University of Chicago
Data source: University of Chicago

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations