deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 1-arm NCT04160546

Study to Evaluate the Reinduction and Second Stop of TKI with Ponatinib in CML in Molecular Response (ResToP) (ResToP)

Multicenter, Open-Label, Single Arm, Phase II Exploratory Study to Evaluate the Reinduction and Second Stop of TKI with Ponatinib in CML in Molecular Response (ResToP)

Sponsor: Apices Soluciones S.L.

Updated 16 times since 2019 Last updated: Dec 30, 2024 Started: Jan 17, 2020 Primary completion: Dec 31, 2025 Completion: Dec 31, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04160546, this PHASE2 trial focuses on Chronic Myeloid Leukemia, Chronic Phase and remains ongoing. Sponsored by Apices Soluciones S.L., it has been updated 16 times since 2020, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Apr 2020 · 3 months · monthly snapshot~Apr 2020 – ~Nov 2020 · 7 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Sep 2021 · 7 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Mar 2022 · 5 months · monthly snapshot~Mar 2022 – ~Sep 2022 · 6 months · monthly snapshot~Sep 2022 – ~Mar 2023 · 6 months · monthly snapshot~Mar 2023 – ~Jan 2024 · 10 months · monthly snapshot~Jan 2024 – ~Jul 2024 · 6 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – ~Sep 2025 · 7 months · monthly snapshot~Sep 2025 – present · 12 months · monthly snapshot

Change History

16 versions recorded
  1. Sep 2025 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Feb 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE2

  3. Sep 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Jan 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

Show 11 earlier versions
  1. Mar 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  2. Sep 2022 — Mar 2023 [monthly]

    Recruiting PHASE2

  3. Mar 2022 — Sep 2022 [monthly]

    Recruiting PHASE2

  4. Oct 2021 — Mar 2022 [monthly]

    Recruiting PHASE2

  5. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  6. Feb 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  7. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE2

  8. Nov 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  9. Apr 2020 — Nov 2020 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  10. Jan 2020 — Apr 2020 [monthly]

    Not Yet Recruiting PHASE2

  11. Dec 2019 — Jan 2020 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Apices Soluciones S.L.
  • Fundacion CRIS de Investigación para Vencer el Cáncer
  • Incyte Biosciences UK
Data source: Fundacion CRIS de Investigación para Vencer el Cáncer

For direct contact, visit the study record on ClinicalTrials.gov .