deltatrials
Completed PHASE2 INTERVENTIONAL 1-arm NCT04173507

Combination Treatment (Talazoparib Plus Avelumab) for Stage IV or Recurrent Non-Squamous Non-Small Cell Lung Cancer With STK11 Gene Mutation (A LUNG-MAP Treatment Trial)

A Phase II Study of Talazoparib Plus Avelumab in Patients With Stage IV or Recurrent Non-Squamous Non-Small Cell Lung Cancer Bearing Pathogenic STK11 Genomic Alterations (LUNG-MAP Sub-Study)

Sponsor: National Cancer Institute (NCI)

Updated 14 times since 2019 Last updated: Aug 14, 2024 Started: Feb 14, 2020 Primary completion: Nov 24, 2021 Completion: May 1, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Advanced Lung Non-Squamous Non-Small Cell Carcinoma and Recurrent Lung Non-Squamous Non-Small Cell Carcinoma and is currently completed. National Cancer Institute (NCI) leads this study, which shows 14 recorded versions since 2020 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Dec 2019 – ~May 2020 · 5 months · monthly snapshot~May 2020 – ~Sep 2020 · 4 months · monthly snapshot~Sep 2020 – ~Jan 2021 · 4 months · monthly snapshot~Jan 2021 – ~Oct 2021 · 9 months · monthly snapshot~Oct 2021 – ~Jun 2022 · 8 months · monthly snapshot~Jun 2022 – ~Feb 2023 · 8 months · monthly snapshot~Feb 2023 – ~Apr 2023 · 59 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jan 2024 · 8 months · monthly snapshot~Jan 2024 – ~Jul 2024 · 6 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Sep 2025 · 11 months · monthly snapshot~Sep 2025 – present · 8 months · monthly snapshot

Change History

14 versions recorded
  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. Oct 2024 — Sep 2025 [monthly]

    Completed PHASE2

    Status: Active Not RecruitingCompleted

  3. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Jan 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

Show 9 earlier versions
  1. May 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE2

  2. Apr 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE2

  3. Feb 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE2

  4. Jun 2022 — Feb 2023 [monthly]

    Active Not Recruiting PHASE2

  5. Oct 2021 — Jun 2022 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  6. Jan 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  7. Sep 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  8. May 2020 — Sep 2020 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  9. Dec 2019 — May 2020 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
  • SWOG Cancer Research Network
Data source: SWOG Cancer Research Network

For direct contact, visit the study record on ClinicalTrials.gov .