Cognitive and Brain Development in Adolescents With Gilles de la Tourette Syndrome (CADETS)

Thus, the aims of the present project is threefold: Aim 1: To evaluate the maturation of cognitive functions in adolescents with TS compared to typically developing adolescents. To achieve this aim, three distinct cognitive dimensions will be assessed in all subjects (patients and controls): (i) reward sensitivity and habit formation; (ii) cognitive impulsivity and action control and (iii) self-agency. Aim 2: To identify neuronal correlates of cognitive function and brain development in health and disease. To achieve this aim, we will use a combined behavioural (as described in Aim 1), (i) neuroimaging and (ii) TMS approaches. Aim 3: To predict clinical outcome . In this part of the project we aim to identify behavioural, imaging or neurophysiological markers of clinical outcome in patients with TS.