deltatrials
Active Not Recruiting PHASE1 INTERVENTIONAL 8-arm NCT04188548

A Study of LY3484356 in Participants With Advanced or Metastatic Breast Cancer or Endometrial Cancer (EMBER)

EMBER: A Phase 1a/1b Study of LY3484356 Administered as Monotherapy and in Combination With Anticancer Therapies for Patients With ER+ Locally Advanced or Metastatic Breast Cancer and Other Select Non-Breast Cancers

Sponsor: Eli Lilly and Company

Conditions Advanced Breast Cancer Breast Cancer Endometrial Cancer Metastatic Breast Cancer
Interventions Abemaciclib Alpelisib Aromatase Inhibitor (AI) Everolimus LY3484356 Pertuzumab Trastuzumab
Updated 48 times since 2020 Last updated: Jun 3, 2025 Started: Dec 10, 2019 Primary completion: Jun 29, 2020 Completion: Dec 31, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04188548, this PHASE1 trial focuses on Advanced Breast Cancer and Breast Cancer and remains ongoing. Sponsored by Eli Lilly and Company, it has been updated 48 times since 2019, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~Jun 2020 · 2 months · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Apr 2024 · 11 months · monthly snapshot~Apr 2024 – ~Jun 2024 · 2 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Feb 2025 · 4 months · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~May 2025 · 2 months · monthly snapshot~May 2025 – ~Jul 2025 · 2 months · monthly snapshot~Jul 2025 – ~Sep 2025 · 2 months · monthly snapshot~Sep 2025 – ~Dec 2025 · 3 months · monthly snapshot~Dec 2025 – present · 8 months · monthly snapshot

Change History

48 versions recorded

  1. Dec 2025 — Present [monthly]

    Active Not Recruiting PHASE1

  2. Sep 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE1

  3. Jul 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE1

  4. May 2025 — Jul 2025 [monthly]

    Active Not Recruiting PHASE1

  5. Mar 2025 — May 2025 [monthly]

    Active Not Recruiting PHASE1

▶ Show 43 earlier versions

  1. Feb 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE1

  2. Oct 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE1

  3. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE1

  4. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  5. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE1

  6. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

  7. Apr 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE1

  8. May 2023 — Apr 2024 [monthly]

    Active Not Recruiting PHASE1

  9. Apr 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  10. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE1

  11. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE1

  12. Jan 2023 — Feb 2023 [monthly]

    Recruiting PHASE1

  13. Dec 2022 — Jan 2023 [monthly]

    Recruiting PHASE1

  14. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE1

  15. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE1

  16. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE1

  17. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE1

  18. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE1

  19. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE1

  20. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE1

  21. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE1

  22. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE1

  23. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE1

  24. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE1

  25. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE1

  26. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE1

  27. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  28. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE1

  29. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE1

  30. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE1

  31. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE1

  32. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE1

  33. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  34. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE1

  35. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE1

  36. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE1

  37. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE1

  38. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE1

  39. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE1

  40. Apr 2020 — Jun 2020 [monthly]

    Recruiting PHASE1

  41. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE1

  42. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE1

  43. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE1

    First recorded

Dec 2019

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Eli Lilly and Company
Data source: Eli Lilly and Company

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Adelaide, Australia , Akashi, Japan , Anderlecht, Belgium , Atlanta, United States , Baltimore, United States , Barcelona, Spain , Beverly Hills, United States , Boston, United States , Burlington, United States , Chuo-ku, Japan and 42 more locations