Active Not Recruiting NA INTERVENTIONAL 20-arm NCT04217551

Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (ICECAP)

Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients - A Multicenter, Randomized, Adaptive Clinical Trial to Identify the Optimal Duration of Induced Hypothermia for Neuroprotection in Comatose Survivors of Cardiac Arrest

Sponsor: Johns Hopkins University

Conditions Cardiac Arrest, Out-Of-Hospital Hypothermia, Induced Hypoxia-Ischemia, Brain

Interventions Therapeutic Hypothermia

Updated 22 times since 2020 Last updated: Jun 18, 2025 Started: May 18, 2020 Primary completion: Sep 5, 2025 Completion: Sep 5, 2025

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A NA clinical study on Cardiac Arrest, Out-Of-Hospital and Hypothermia, Induced, this trial is ongoing. The trial is conducted by Johns Hopkins University and has accumulated 22 data snapshots since 2020. Cardiovascular trials of this type often inform treatment guidelines for long-term patient management.

Status Flow

Change History

22 versions recorded

Sep 2025 — Present [monthly]

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▶ Show 17 earlier versions

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First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Johns Hopkins University
Medical University of South Carolina
National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health (NIH)
University of Michigan

Data source: University of Michigan

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Albuquerque, United States , Ann Arbor, United States , Atlanta, United States , Aurora, United States , Baltimore, United States , Bay Shore, United States , Birmingham, United States , Boston, United States , Camden, United States , Charlottesville, United States and 49 more locations