Unknown PHASE4 INTERVENTIONAL 3-arm NCT04225312

Personalized Extended Interval Dosing of Natalizumab in Relapsing Remitting Multiple Sclerosis (SUPERNEXT)

Sponsor: Amsterdam UMC, location VUmc

Conditions Relapsing Remitting Multiple Sclerosis

Interventions Personalized extended interval dosing of natalizumab Standard interval dosing

Updated 10 times since 2020 Last updated: Apr 25, 2023 Started: Feb 3, 2020 Primary completion: Mar 1, 2025 Completion: Mar 1, 2025

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE4 clinical study on Relapsing Remitting Multiple Sclerosis, this trial is ongoing. The trial is conducted by Amsterdam UMC, location VUmc and has accumulated 10 data snapshots since 2020. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

Change History

10 versions recorded

Sep 2025 — Present [monthly]

Unknown PHASE4
May 2025 — Sep 2025 [monthly]

Unknown PHASE4

Status: Enrolling By Invitation → Unknown
Sep 2024 — May 2025 [monthly]

Enrolling By Invitation PHASE4
Jul 2024 — Sep 2024 [monthly]

Enrolling By Invitation PHASE4
May 2023 — Jul 2024 [monthly]

Enrolling By Invitation PHASE4

Status: Recruiting → Enrolling By Invitation

▶ Show 5 earlier versions

May 2022 — May 2023 [monthly]

Recruiting PHASE4
Oct 2021 — May 2022 [monthly]

Recruiting PHASE4
Jan 2021 — Oct 2021 [monthly]

Recruiting PHASE4
Jun 2020 — Jan 2021 [monthly]

Recruiting PHASE4
Feb 2020 — Jun 2020 [monthly]

Recruiting PHASE4

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Amsterdam UMC, location VUmc
Innovatiefonds Zorgverzekeraars
Stichting MS Research
Stichting Treatmeds

Data source: Amsterdam UMC, location VUmc

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

's-Hertogenbosch, Netherlands , Almelo, Netherlands , Almere Stad, Netherlands , Amsterdam, Netherlands , Arnhem, Netherlands , Assen, Netherlands , Breda, Netherlands , Delft, Netherlands , Doetinchem, Netherlands , Groningen, Netherlands and 11 more locations