deltatrials
Completed PHASE2 INTERVENTIONAL 9-arm NCT04225715

A Trial To Evaluate The Efficacy And Safety Of Multiple Combination Therapies In Participants With Chronic Hepatitis B (Piranga)

A Phase II, Randomised, Adaptive, Open-Label Platform Trial To Evaluate Efficacy And Safety Of Multiple Combination Therapies In Participants With Chronic Hepatitis B

Sponsor: Hoffmann-La Roche

Conditions Hepatitis B, Chronic
Interventions CpAM (RO7049389) Nucleos(t)ide (NUC) PD-L1 LNA (RO7191863) PEG-IFN TLR7 (RO7020531) siRNA (RO7445482)
Updated 34 times since 2020 Last updated: Aug 29, 2025 Started: Jul 5, 2020 Primary completion: Jul 19, 2024 Completion: Jul 19, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04225715, this PHASE2 trial focuses on Hepatitis B, Chronic and remains completed. Sponsored by Hoffmann-La Roche, it has been updated 34 times since 2020, reflecting substantial change activity. This study is part of the global effort to build evidence for infectious disease interventions.

Status Flow

~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2022 · 13 months · monthly snapshot~Mar 2022 – ~May 2022 · 2 months · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Jan 2023 · 4 months · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Oct 2023 · 3 months · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Feb 2024 · 3 months · monthly snapshot~Feb 2024 – ~May 2024 · 3 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Dec 2025 · 2 months · monthly snapshot~Dec 2025 – present · 7 months · monthly snapshot

Change History

34 versions recorded

  1. Dec 2025 — Present [monthly]

    Completed PHASE2

  2. Oct 2025 — Dec 2025 [monthly]

    Completed PHASE2

  3. Sep 2025 — Oct 2025 [monthly]

    Completed PHASE2

  4. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  5. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

▶ Show 29 earlier versions

  1. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE2

  2. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  3. Feb 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE2

  4. Nov 2023 — Feb 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Oct 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE2

  6. Jul 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  7. Jun 2023 — Jul 2023 [monthly]

    Recruiting PHASE2

  8. May 2023 — Jun 2023 [monthly]

    Recruiting PHASE2

  9. Apr 2023 — May 2023 [monthly]

    Recruiting PHASE2

  10. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE2

  11. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE2

  12. Jan 2023 — Feb 2023 [monthly]

    Recruiting PHASE2

  13. Sep 2022 — Jan 2023 [monthly]

    Recruiting PHASE2

  14. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE2

  15. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE2

  16. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE2

  17. Mar 2022 — May 2022 [monthly]

    Recruiting PHASE2

  18. Feb 2021 — Mar 2022 [monthly]

    Recruiting PHASE2

  19. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE2

  20. Nov 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  21. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE2

  22. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE2

  23. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE2

  24. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE2

  25. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  26. May 2020 — Jun 2020 [monthly]

    Not Yet Recruiting PHASE2

  27. Apr 2020 — May 2020 [monthly]

    Not Yet Recruiting PHASE2

  28. Mar 2020 — Apr 2020 [monthly]

    Not Yet Recruiting PHASE2

  29. Feb 2020 — Mar 2020 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Hoffmann-La Roche
Data source: Hoffmann-La Roche

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Auckland, New Zealand , Bangkok, Thailand , Barcelona, Spain , Beijing, China , Calgary, Canada , Chang-hua, Taiwan , Changchun, China , Chengdu, China , Chiang Mai, Thailand , Clichy, France and 16 more locations