deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT04255433

A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes (SURPASS-CVOT)

The Effect of Tirzepatide Versus Dulaglutide on Major Adverse Cardiovascular Events in Patients With Type 2 Diabetes (SURPASS-CVOT)

Sponsor: Eli Lilly and Company

Conditions Type 2 Diabetes Mellitus
Interventions Dulaglutide Tirzepatide
Updated 53 times since 2020 Last updated: Aug 22, 2025 Started: May 29, 2020 Primary completion: Jun 12, 2025 Completion: Jun 12, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04255433, this PHASE3 trial focuses on Type 2 Diabetes Mellitus and remains completed. Sponsored by Eli Lilly and Company, it has been updated 53 times since 2020, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Oct 2023 · 2 months · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~May 2024 · 6 months · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Jan 2025 · 2 months · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~May 2025 · 2 months · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Aug 2025 · 2 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Dec 2025 · 3 months · monthly snapshot~Dec 2025 – present · 5 months · monthly snapshot

Change History

53 versions recorded

  1. Dec 2025 — Present [monthly]

    Completed PHASE3

  2. Sep 2025 — Dec 2025 [monthly]

    Completed PHASE3

  3. Aug 2025 — Sep 2025 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  4. Jun 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE3

  5. May 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE3

▶ Show 48 earlier versions

  1. Mar 2025 — May 2025 [monthly]

    Active Not Recruiting PHASE3

  2. Feb 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE3

  3. Jan 2025 — Feb 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Nov 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Sep 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE3

  6. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

  7. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

  8. May 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE3

  9. Nov 2023 — May 2024 [monthly]

    Active Not Recruiting PHASE3

  10. Oct 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE3

  11. Aug 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE3

  12. Jul 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE3

  13. Jun 2023 — Jul 2023 [monthly]

    Active Not Recruiting PHASE3

  14. May 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE3

  15. Apr 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE3

  16. Mar 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE3

  17. Feb 2023 — Mar 2023 [monthly]

    Active Not Recruiting PHASE3

  18. Jan 2023 — Feb 2023 [monthly]

    Active Not Recruiting PHASE3

  19. Dec 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE3

  20. Nov 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE3

  21. Sep 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  22. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE3

  23. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE3

  24. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE3

  25. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE3

  26. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE3

  27. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE3

  28. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE3

  29. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE3

  30. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE3

  31. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE3

  32. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE3

  33. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE3

  34. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE3

  35. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE3

  36. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE3

  37. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE3

  38. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE3

  39. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE3

  40. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE3

  41. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE3

  42. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE3

  43. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE3

  44. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE3

    Status: Not Yet Recruiting → Recruiting

  45. Jun 2020 — Jul 2020 [monthly]

    Not Yet Recruiting PHASE3

  46. May 2020 — Jun 2020 [monthly]

    Not Yet Recruiting PHASE3

  47. Apr 2020 — May 2020 [monthly]

    Not Yet Recruiting PHASE3

  48. Mar 2020 — Apr 2020 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Eli Lilly and Company
Data source: Eli Lilly and Company

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

's-Hertogenbosch, Netherlands , A Coruña, Spain , Aalst, Belgium , Aberdeen, United Kingdom , Adelaide, Australia , Afula, Israel , Aguascalientes, Mexico , Ahmedabad, India , Alba Iulia, Romania , Albany, United States and 468 more locations