deltatrials
Completed PHASE2 INTERVENTIONAL 1-arm NCT04256759

Dupilumab for the Treatment of Moderate to Severe Chronic Hepatic Pruritus

Dupilumab for the Treatment of Moderate to Severe Chronic Hepatic Pruritus: an Open-Label, Single-Arm, Exploratory Study

Sponsor: Mayo Clinic

Conditions Pruritus
Updated 13 times since 2020 Last updated: Nov 10, 2025 Started: Sep 1, 2020 Primary completion: Sep 6, 2024 Completion: Sep 6, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04256759, this PHASE2 trial focuses on Pruritus and remains completed. Sponsored by Mayo Clinic, it has been updated 13 times since 2020, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~Aug 2020 · 4 months · monthly snapshot~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Dec 2021 · 11 months · monthly snapshot~Dec 2021 – ~Jan 2023 · 13 months · monthly snapshot~Jan 2023 – ~Nov 2023 · 10 months · monthly snapshot~Nov 2023 – ~Jun 2024 · 7 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – ~Dec 2025 · 10 months · monthly snapshot~Dec 2025 – present · 8 months · monthly snapshot

Change History

13 versions recorded
  1. Dec 2025 — Present [monthly]

    Completed PHASE2

    Status: Active Not RecruitingCompleted

  2. Feb 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  3. Sep 2024 — Feb 2025 [monthly]

    Recruiting PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  5. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE2

Show 8 earlier versions
  1. Nov 2023 — Jun 2024 [monthly]

    Recruiting PHASE2

  2. Jan 2023 — Nov 2023 [monthly]

    Recruiting PHASE2

  3. Dec 2021 — Jan 2023 [monthly]

    Recruiting PHASE2

  4. Jan 2021 — Dec 2021 [monthly]

    Recruiting PHASE2

  5. Oct 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  6. Aug 2020 — Oct 2020 [monthly]

    Not Yet Recruiting PHASE2

  7. Apr 2020 — Aug 2020 [monthly]

    Not Yet Recruiting PHASE2

  8. Mar 2020 — Apr 2020 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Mayo Clinic
  • Regeneron Pharmaceuticals
Data source: Mayo Clinic

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations