deltatrials
Completed PHASE4 INTERVENTIONAL 3-arm NCT04276259

Rapid Antidepressant Improvement Secondary to Excitatory Brain Responses (RAISE)

Neurocomputational Mechanisms of Mood Improvement

Sponsor: Marta Peciña, MD PhD

Updated 16 times since 2020 Last updated: Feb 10, 2026 Started: Oct 19, 2020 Primary completion: Jan 21, 2026 Completion: Jan 21, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04276259, this PHASE4 trial focuses on Depression and Major Depressive Disorder and remains completed. Sponsored by Marta Peciña, MD PhD, it has been updated 16 times since 2020, reflecting substantial change activity. Mental health research at this phase helps define safety and dosing parameters for future study.

Status Flow

~Mar 2020 – ~May 2020 · 2 months · monthly snapshot~May 2020 – ~Oct 2020 · 5 months · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Feb 2022 · 11 months · monthly snapshot~Feb 2022 – ~May 2022 · 3 months · monthly snapshot~May 2022 – ~Apr 2023 · 11 months · monthly snapshot~Apr 2023 – ~Mar 2024 · 11 months · monthly snapshot~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Jul 2025 · 10 months · monthly snapshot~Jul 2025 – ~Jan 2026 · 6 months · monthly snapshot~Jan 2026 – ~Feb 2026 · 31 days · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

16 versions recorded
  1. Feb 2026 — Present [monthly]

    Completed PHASE4

    Status: Active Not RecruitingCompleted

  2. Jan 2026 — Feb 2026 [monthly]

    Active Not Recruiting PHASE4

    Status: RecruitingActive Not Recruiting

  3. Jul 2025 — Jan 2026 [monthly]

    Recruiting PHASE4

  4. Sep 2024 — Jul 2025 [monthly]

    Recruiting PHASE4

  5. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE4

Show 11 earlier versions
  1. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE4

  2. Mar 2024 — Jul 2024 [monthly]

    Recruiting PHASE4

  3. Apr 2023 — Mar 2024 [monthly]

    Recruiting PHASE4

  4. May 2022 — Apr 2023 [monthly]

    Recruiting PHASE4

  5. Feb 2022 — May 2022 [monthly]

    Recruiting PHASE4

  6. Mar 2021 — Feb 2022 [monthly]

    Recruiting PHASE4

  7. Jan 2021 — Mar 2021 [monthly]

    Recruiting PHASE4

  8. Nov 2020 — Jan 2021 [monthly]

    Recruiting PHASE4

    Status: Not Yet RecruitingRecruiting

  9. Oct 2020 — Nov 2020 [monthly]

    Not Yet Recruiting PHASE4

  10. May 2020 — Oct 2020 [monthly]

    Not Yet Recruiting PHASE4

  11. Mar 2020 — May 2020 [monthly]

    Not Yet Recruiting PHASE4

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Marta Peciña, MD PhD
  • National Institute of Mental Health (NIMH)
Data source: University of Pittsburgh

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations