deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT04280705

Adaptive COVID-19 Treatment Trial (ACTT)

A Multicenter, Adaptive, Randomized Blinded Controlled Trial of the Safety and Efficacy of Investigational Therapeutics for the Treatment of COVID-19 in Hospitalized Adults

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Conditions COVID-19
Updated 12 times since 2020 Last updated: Mar 9, 2022 Started: Feb 21, 2020 Primary completion: May 21, 2020 Completion: May 21, 2020
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04280705, this PHASE3 trial focuses on COVID-19 and remains completed. Sponsored by National Institute of Allergy and Infectious Diseases (NIAID), it has been updated 12 times since 2020, reflecting substantial change activity. This study is part of the global effort to build evidence for infectious disease interventions.

Status Flow

~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshotRecruiting~Apr 2020 – ~May 2020 · 30 days · monthly snapshotRecruiting~May 2020 – ~Jun 2020 · 31 days · monthly snapshotRecruiting~Jun 2020 – ~Aug 2020 · 2 months · monthly snapshotRecruiting~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshotCompleted~Oct 2020 – ~Dec 2020 · 2 months · monthly snapshotCompleted~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshotCompleted~Jan 2021 – ~Apr 2022 · 15 months · monthly snapshotCompleted~Apr 2022 – ~Jul 2024 · 27 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotCompleted~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshotCompleted~Sep 2025 – present · 9 months · monthly snapshotCompleted

Change History

12 versions recorded
  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE3

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  4. Apr 2022 — Jul 2024 [monthly]

    Completed PHASE3

  5. Jan 2021 — Apr 2022 [monthly]

    Completed PHASE3

Show 7 earlier versions
  1. Dec 2020 — Jan 2021 [monthly]

    Completed PHASE3

  2. Oct 2020 — Dec 2020 [monthly]

    Completed PHASE3

  3. Aug 2020 — Oct 2020 [monthly]

    Completed PHASE3

    Status: RecruitingCompleted

  4. Jun 2020 — Aug 2020 [monthly]

    Recruiting PHASE3

  5. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE3

  6. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE3

    Phase: PHASE2PHASE3

  7. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE2

    First recorded

Feb 2020

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Institute of Allergy and Infectious Diseases (NIAID)
Data source: National Institute of Allergy and Infectious Diseases (NIAID)

For direct contact, visit the study record on ClinicalTrials.gov .