deltatrials
Recruiting PHASE2/PHASE3 INTERVENTIONAL 2-arm NCT04299893

Ozone Therapy in Chemotherapy-induced Peripheral Neuropathy: RCT (O3NPIQ) (O3NPIQ)

Effectiveness and Cost-effectiveness of Ozone Therapy in Patients With Pain Secondary to Chemotherapy-induced Peripheral Neuropathy. Randomized, Triple-blind Clinical Trial (O3NPIQ)

Sponsor: Bernardino Clavo, MD, PhD

Interventions Oxygen Ozone
Updated 11 times since 2020 Last updated: Aug 25, 2025 Started: Nov 30, 2020 Primary completion: Sep 30, 2027 Completion: Dec 31, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04299893, this PHASE2/PHASE3 trial focuses on Chemotherapy-induced Peripheral Neuropathy and Pain Syndrome and remains actively recruiting participants. Sponsored by Bernardino Clavo, MD, PhD, it has been updated 11 times since 2020, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Apr 2020 – ~Sep 2020 · 5 months · monthly snapshotNot Yet Recruiting~Sep 2020 – ~Jan 2021 · 4 months · monthly snapshotNot Yet Recruiting~Jan 2021 – ~Oct 2021 · 9 months · monthly snapshotRecruiting~Oct 2021 – ~May 2022 · 7 months · monthly snapshotRecruiting~May 2022 – ~Dec 2022 · 7 months · monthly snapshotRecruiting~Dec 2022 – ~Apr 2024 · 16 months · monthly snapshotRecruiting~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotRecruiting~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshotRecruiting~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshotRecruiting~Oct 2025 – present · 9 months · monthly snapshotRecruiting

Change History

11 versions recorded
  1. Oct 2025 — Present [monthly]

    Recruiting PHASE2/PHASE3

  2. Sep 2025 — Oct 2025 [monthly]

    Recruiting PHASE2/PHASE3

  3. Sep 2024 — Sep 2025 [monthly]

    Recruiting PHASE2/PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2/PHASE3

    Phase: PHASE2_PHASE3PHASE2/PHASE3

  5. Apr 2024 — Jul 2024 [monthly]

    Recruiting PHASE2_PHASE3

Show 6 earlier versions
  1. Dec 2022 — Apr 2024 [monthly]

    Recruiting PHASE2_PHASE3

  2. May 2022 — Dec 2022 [monthly]

    Recruiting PHASE2_PHASE3

  3. Oct 2021 — May 2022 [monthly]

    Recruiting PHASE2_PHASE3

  4. Jan 2021 — Oct 2021 [monthly]

    Recruiting PHASE2_PHASE3

    Status: Not Yet RecruitingRecruiting

  5. Sep 2020 — Jan 2021 [monthly]

    Not Yet Recruiting PHASE2_PHASE3

  6. Apr 2020 — Sep 2020 [monthly]

    Not Yet Recruiting PHASE2_PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Bernardino Clavo, MD, PhD
  • Fundación DISA, Spain
  • Fundación Española del Dolor (FED)
  • Instituto de Salud Carlos III
  • Red de Investigación en Servicios de Salud en Enfermedades Crónicas
  • Servicio Canario de Salud
Data source: Dr. Negrin University Hospital

For direct contact, visit the study record on ClinicalTrials.gov .