deltatrials
Completed PHASE2 INTERVENTIONAL 1-arm NCT04307186

Study to Find the Appropriate Dose of a New Gadolinium-based Contrast Agent (GBCA) for Adults Undergoing Magnetic Resonance Imaging (MRI) for Known or Highly Suspected Brain and/or Spinal Cord Conditions

Multicenter, Single-blind, Adaptive Dose Finding Study of Single Intravenous Injections of BAY 1747846 With Corresponding Blinded Read in Adult Participants With Known or Highly Suspected CNS Lesions Referred for Contrast-enhanced MRI of the CNS

Sponsor: Bayer

Conditions Central Nervous System Pathology
Interventions Gadobutrol (Gadovist/Gadavist) Gadoquatrane (BAY1747846)
Updated 31 times since 2020 Last updated: Oct 24, 2023 Started: Nov 18, 2020 Primary completion: Sep 5, 2022 Completion: Sep 6, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04307186, this PHASE2 trial focuses on Central Nervous System Pathology and remains completed. Sponsored by Bayer, it has been updated 31 times since 2020, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Nov 2021 · 2 months · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Dec 2023 · 11 months · monthly snapshot~Dec 2023 – ~Jul 2024 · 7 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 21 months · monthly snapshot

Change History

31 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed PHASE2

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  3. Dec 2023 — Jul 2024 [monthly]

    Completed PHASE2

  4. Jan 2023 — Dec 2023 [monthly]

    Completed PHASE2

    Status: Recruiting → Completed

  5. Dec 2022 — Jan 2023 [monthly]

    Recruiting PHASE2

    Status: Active Not Recruiting → Recruiting

▶ Show 26 earlier versions

  1. Nov 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  2. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE2

  3. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE2

  4. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE2

  5. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE2

  6. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE2

  7. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE2

  8. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE2

  9. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE2

  10. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE2

  11. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE2

  12. Sep 2021 — Nov 2021 [monthly]

    Recruiting PHASE2

  13. May 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  14. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE2

  15. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

  16. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE2

  17. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  18. Dec 2020 — Jan 2021 [monthly]

    Not Yet Recruiting PHASE2

  19. Nov 2020 — Dec 2020 [monthly]

    Not Yet Recruiting PHASE2

  20. Oct 2020 — Nov 2020 [monthly]

    Not Yet Recruiting PHASE2

  21. Sep 2020 — Oct 2020 [monthly]

    Not Yet Recruiting PHASE2

  22. Aug 2020 — Sep 2020 [monthly]

    Not Yet Recruiting PHASE2

  23. Jul 2020 — Aug 2020 [monthly]

    Not Yet Recruiting PHASE2

  24. Jun 2020 — Jul 2020 [monthly]

    Not Yet Recruiting PHASE2

  25. May 2020 — Jun 2020 [monthly]

    Not Yet Recruiting PHASE2

  26. Apr 2020 — May 2020 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Bayer
Data source: Bayer

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Chicago, United States , Dortmund, Germany , Essen, Germany , Fukuoka, Japan , Hershey, United States , Himeji, Japan , Hiroshima, Japan , Iowa City, United States , Jena, Germany , Kishiwada, Japan and 5 more locations