Unknown NA INTERVENTIONAL 2-arm NCT04322136

AMPLE-3: IPC Plus Talc vs VATS in Management of Malignant Pleural Effusion (AMPLE-3)

The Australasian Malignant PLeural Effusion (AMPLE) Trial - 3: A Randomised Study of the Relative Benefits of Combined Indwelling Pleural Catheter (IPC) and Talc Pleurodesis Therapy or Video-Assisted Thoracoscopic Surgery (VATS) in the Management of Patients With Malignant Pleural Effusion.

Sponsor: Auckland City Hospital

Conditions Cancer Malignant Pleural Effusion Respiratory Disease

Interventions Indwelling pleural catheter (with talc pleurodesis if suitable) Pleurodesis via Video-assisted thoracoscopic surgery

Updated 9 times since 2020 Last updated: Dec 3, 2023 Started: May 29, 2018 Primary completion: Dec 31, 2024 Completion: Dec 31, 2025

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This NA trial investigates Cancer and Malignant Pleural Effusion and is currently ongoing. Auckland City Hospital leads this study, which shows 9 recorded versions since 2018 — indicating limited longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

Change History

9 versions recorded

Feb 2026 — Present [monthly]

Unknown NA

Status: Recruiting → Unknown
Sep 2024 — Feb 2026 [monthly]

Recruiting NA
Jul 2024 — Sep 2024 [monthly]

Recruiting NA
Jan 2024 — Jul 2024 [monthly]

Recruiting NA
Jun 2023 — Jan 2024 [monthly]

Recruiting NA

▶ Show 4 earlier versions

Oct 2021 — Jun 2023 [monthly]

Recruiting NA
May 2021 — Oct 2021 [monthly]

Recruiting NA
Jan 2021 — May 2021 [monthly]

Recruiting NA
Apr 2020 — Jan 2021 [monthly]

Recruiting NA

First recorded

May 2018

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Auckland City Hospital
Concord Hospital
Fiona Stanley Hospital
Guy's and St Thomas' NHS Foundation Trust
Hollywood Private Hospital, Australia
Hospital Queen Elizabeth, Malaysia
John Hunter Hospital
Johns Hopkins University
Northern Hospital, Australia
Royal Adelaide Hospital, Australia
Sir Charles Gairdner Hospital
St John of God Midland Hospital, Australia
St John of God Murdoch Hospital, Australia
St Vincent's Hospital Melbourne
Sunshine Coast Hospital and Health Service
The Prince Charles Hospital
The Sutherland and St George Hospitals, Australia
The University of Western Australia
Toronto General Hospital
Universiti Kebangsaan Malaysia Medical Centre
Vanderbilt University Medical Center
Wellington Hospital
Wesley Hospital, Australia
Westmead Hospital, Australia

Data source: The University of Western Australia

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Nedlands, Australia