deltatrials
Completed PHASE2 INTERVENTIONAL 2-arm NCT04361331

Two-cohort Study of Toripalimab(PD1)+Lenvatnib, or Gemox+Lenvatinib in Advanced Intrahepatic Cholangiocarcinoma

A Randomized, Open, Two-cohort Phase 2 Study of Toripalimab(PD1) Combined With Lenvatnib, or Gemox Chemotherapy Combined With Lenvatinib as First-line Therapy in Patients With Advanced or Unresectable Intrahepatic Cholangiocarcinoma

Sponsor: Shanghai Zhongshan Hospital

Conditions Cholangiocarcinoma, Intrahepatic
Interventions Lenvatinib combined with gemox Toripalimab combined with lenvatinib
Updated 8 times since 2020 Last updated: Feb 4, 2025 Started: Mar 6, 2020 Primary completion: Sep 1, 2023 Completion: Sep 1, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Cholangiocarcinoma, Intrahepatic and is currently completed. Shanghai Zhongshan Hospital leads this study, which shows 8 recorded versions since 2020 — indicating limited longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~May 2020 – ~Jan 2021 · 8 months · monthly snapshotRecruiting~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshotRecruiting~Sep 2021 – ~Aug 2023 · 23 months · monthly snapshotActive Not Recruiting~Aug 2023 – ~Jul 2024 · 11 months · monthly snapshotUnknown Status~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Mar 2025 · 6 months · monthly snapshot~Mar 2025 – ~Jun 2025 · 3 months · monthly snapshot~Jun 2025 – present · 13 months · monthly snapshotCompleted

Change History

8 versions recorded

  1. Jun 2025 — Present [monthly]

    Completed PHASE2

  2. Mar 2025 — Jun 2025 [monthly]

    Completed PHASE2

    Status: Unknown → Completed

  3. Sep 2024 — Mar 2025 [monthly]

    Unknown PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Unknown PHASE2

    Status: Unknown Status → Unknown

  5. Aug 2023 — Jul 2024 [monthly]

    Unknown Status PHASE2

    Status: Active Not Recruiting → Unknown Status

▶ Show 3 earlier versions

  1. Sep 2021 — Aug 2023 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  2. Jan 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  3. May 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

    First recorded

Mar 2020

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Shanghai Zhongshan Hospital
Data source: Shanghai Zhongshan Hospital

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations