deltatrials
Completed PHASE2 INTERVENTIONAL 2-arm NCT04374630

Study With Afuresertib and Paclitaxel in Platinum Resistant Ovarian (PROFECTA-II)

An Open Label Randomized Active Controlled Phase II Clinical Study to Assess the Efficacy and Safety of Afuresertib Plus Paclitaxel Versus Paclitaxel in Patients With Platinum-Resistant Ovarian Cancer

Sponsor: Laekna Limited

Updated 18 times since 2020 Last updated: Sep 3, 2025 Started: Jun 9, 2020 Primary completion: Jul 31, 2023 Completion: Jun 28, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Platinum-resistant Ovarian Cancer and is currently completed. Laekna Limited leads this study, which shows 18 recorded versions since 2020 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jun 2020 – ~Oct 2020 · 4 months · monthly snapshot~Oct 2020 – ~Dec 2020 · 2 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Dec 2021 · 8 months · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Jun 2022 · 5 months · monthly snapshot~Jun 2022 – ~Sep 2022 · 3 months · monthly snapshot~Sep 2022 – ~Jan 2023 · 4 months · monthly snapshot~Jan 2023 – ~Sep 2023 · 8 months · monthly snapshot~Sep 2023 – ~Jan 2024 · 4 months · monthly snapshot~Jan 2024 – ~Apr 2024 · 3 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Apr 2025 · 7 months · monthly snapshot~Apr 2025 – ~Sep 2025 · 5 months · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – present · 9 months · monthly snapshot

Change History

18 versions recorded
  1. Oct 2025 — Present [monthly]

    Completed PHASE2

  2. Sep 2025 — Oct 2025 [monthly]

    Completed PHASE2

  3. Apr 2025 — Sep 2025 [monthly]

    Completed PHASE2

  4. Sep 2024 — Apr 2025 [monthly]

    Completed PHASE2

    Status: Active Not RecruitingCompleted

  5. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

Show 13 earlier versions
  1. Apr 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  2. Jan 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE2

  3. Sep 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  4. Jan 2023 — Sep 2023 [monthly]

    Recruiting PHASE2

  5. Sep 2022 — Jan 2023 [monthly]

    Recruiting PHASE2

  6. Jun 2022 — Sep 2022 [monthly]

    Recruiting PHASE2

  7. Jan 2022 — Jun 2022 [monthly]

    Recruiting PHASE2

  8. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE2

  9. Apr 2021 — Dec 2021 [monthly]

    Recruiting PHASE2

  10. Jan 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

  11. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  12. Oct 2020 — Dec 2020 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  13. Jun 2020 — Oct 2020 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Laekna Limited
Data source: Laekna Limited

For direct contact, visit the study record on ClinicalTrials.gov .