deltatrials
Active Not Recruiting PHASE3 INTERVENTIONAL 3-arm NCT04380636

Study of Pembrolizumab With Concurrent Chemoradiation Therapy Followed by Pembrolizumab With or Without Olaparib in Stage III Non-Small Cell Lung Cancer (NSCLC) (MK-7339-012/KEYLYNK-012)

A Phase 3 Study of Pembrolizumab (MK-3475) in Combination With Concurrent Chemoradiation Therapy Followed by Pembrolizumab With or Without Olaparib vs Concurrent Chemoradiation Therapy Followed by Durvalumab in Participants With Unresectable, Locally Advanced, Stage III Non-Small Cell Lung Cancer (NSCLC)

Sponsor: Merck Sharp & Dohme LLC

Updated 44 times since 2020 Last updated: Aug 13, 2025 Started: Jul 6, 2020 Primary completion: Jul 6, 2026 Completion: Feb 15, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Carcinoma, Non-Small-Cell Lung and Lung Neoplasms and is currently ongoing. Merck Sharp & Dohme LLC leads this study, which shows 44 recorded versions since 2020 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Feb 2023 · 2 months · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~May 2024 · 4 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Dec 2024 · 3 months · monthly snapshot~Dec 2024 – ~Sep 2025 · 9 months · monthly snapshot~Sep 2025 – present · 11 months · monthly snapshot

Change History

44 versions recorded
  1. Sep 2025 — Present [monthly]

    Active Not Recruiting PHASE3

  2. Dec 2024 — Sep 2025 [monthly]

    Active Not Recruiting PHASE3

  3. Sep 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

  5. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

Show 39 earlier versions
  1. Jan 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE3

    Status: RecruitingActive Not Recruiting

  2. Dec 2023 — Jan 2024 [monthly]

    Recruiting PHASE3

  3. Nov 2023 — Dec 2023 [monthly]

    Recruiting PHASE3

  4. Oct 2023 — Nov 2023 [monthly]

    Recruiting PHASE3

  5. Sep 2023 — Oct 2023 [monthly]

    Recruiting PHASE3

  6. Aug 2023 — Sep 2023 [monthly]

    Recruiting PHASE3

  7. Jul 2023 — Aug 2023 [monthly]

    Recruiting PHASE3

  8. Jun 2023 — Jul 2023 [monthly]

    Recruiting PHASE3

  9. May 2023 — Jun 2023 [monthly]

    Recruiting PHASE3

  10. Apr 2023 — May 2023 [monthly]

    Recruiting PHASE3

  11. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE3

  12. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE3

  13. Dec 2022 — Feb 2023 [monthly]

    Recruiting PHASE3

  14. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE3

  15. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE3

  16. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE3

  17. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE3

  18. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE3

  19. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE3

  20. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE3

  21. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE3

  22. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE3

  23. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE3

  24. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE3

  25. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE3

  26. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE3

  27. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE3

  28. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE3

  29. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE3

  30. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE3

  31. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE3

  32. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE3

  33. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE3

  34. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE3

  35. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE3

  36. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE3

  37. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE3

  38. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE3

    Status: Not Yet RecruitingRecruiting

  39. Jun 2020 — Jul 2020 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Merck Sharp & Dohme LLC
Data source: Merck Sharp & Dohme LLC

For direct contact, visit the study record on ClinicalTrials.gov .