Unknown PHASE4 INTERVENTIONAL 2-arm NCT04412694

The Effect of Preoperative Oral Dexamethasone Supplementation on the Outcome of Thyroidectomised Patients. (Dexa)

The Impact of Preoperative Oral Dexamethasone Supplementation on the Biochemical Parameters and Results of Surgical Treatment in Patients With Nontoxic Multinodular Goiter Undergoing Total Thyroidectomy.

Sponsor: Medical University of Lodz

Conditions Hypocalcemia Hypoparathyroidism Postprocedural Postoperative Complications Postoperative Nausea Postoperative Pain Vitamin D Deficiency Voice Hoarseness

Interventions Dexamethasone oral tablet 8mg (Dexamethasone Krka tablets(8mg), Warsaw, Poland). Placebo oral sweetener (Clio tablets, sweetener with a dispenser, Instantina GES, Vienna, Austria). Postoperative laboratory blood tests at 24 hour Postoperative laboratory blood tests at 6 hour Postoperative laboratory drainage fluid tests at 24 hour Postoperative nausea and vomiting at 24 hour Postoperative nausea and vomiting at 6 hour Postoperative pain at 24 hour Postoperative pain at 6 hour Postoperative sore throat and hoarseness at 24 hour Postoperative sore throat and hoarseness at 6 hour Preoparative blood laboratory tests Symptomatic hypocalcaemia at 24 hour Symptomatic hypocalcaemia at 6 hour Total thyroidectomy

Updated 9 times since 2020 Last updated: Feb 5, 2022 Started: Jul 1, 2020 Primary completion: Sep 30, 2022 Completion: Dec 31, 2022

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE4 trial investigates Hypocalcemia and Hypoparathyroidism Postprocedural and is currently ongoing. Medical University of Lodz leads this study, which shows 9 recorded versions since 2020 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

9 versions recorded

Sep 2025 — Present [monthly]

Unknown PHASE4
Sep 2024 — Sep 2025 [monthly]

Unknown PHASE4
Jul 2024 — Sep 2024 [monthly]

Unknown PHASE4

Status: Unknown Status → Unknown
Mar 2024 — Jul 2024 [monthly]

Unknown Status PHASE4

Status: Recruiting → Unknown Status
Mar 2022 — Mar 2024 [monthly]

Recruiting PHASE4

▶ Show 4 earlier versions

Oct 2021 — Mar 2022 [monthly]

Recruiting PHASE4
Jan 2021 — Oct 2021 [monthly]

Recruiting PHASE4
Oct 2020 — Jan 2021 [monthly]

Recruiting PHASE4

Status: Not Yet Recruiting → Recruiting
Jul 2020 — Oct 2020 [monthly]

Not Yet Recruiting PHASE4

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Medical University of Lodz

Data source: Medical University of Lodz

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Lodz, Poland