deltatrials
Completed PHASE2 INTERVENTIONAL 2-arm NCT04439539

A Study of JNJ-73763989, Pegylated Interferon Alpha-2a, Nucleos(t)Ide Analog (NA) With or Without JNJ-56136379 in Treatment-naive Participants With Hepatitis B e Antigen (HBeAg) Positive Chronic Hepatitis B Virus (HBV) Infection

A Phase 2, Randomized, Open-label, Multicenter Study to Evaluate Efficacy, Pharmacokinetics, Safety, and Tolerability of Treatment With JNJ-73763989, Pegylated Interferon Alpha-2a, Nucleos(t)Ide Analog With or Without JNJ-56136379 in Treatment-naive Patients With HBeAg Positive Chronic Hepatitis B Virus Infection

Sponsor: Janssen Research & Development, LLC

Updated 47 times since 2020 Last updated: Jun 23, 2025 Started: Sep 14, 2020 Primary completion: Aug 29, 2023 Completion: Feb 13, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Hepatitis B, Chronic, this trial is completed. The trial is conducted by Janssen Research & Development, LLC and has accumulated 47 data snapshots since 2020. Infectious disease trials contribute critical data for public health response and treatment development.

Status Flow

~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Apr 2021 · 59 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Dec 2021 · 2 months · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Jan 2025 · 3 months · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Apr 2025 · 59 days · monthly snapshot~Apr 2025 – ~Jul 2025 · 3 months · monthly snapshot~Jul 2025 – ~Sep 2025 · 2 months · monthly snapshot~Sep 2025 – ~Dec 2025 · 3 months · monthly snapshot~Dec 2025 – present · 6 months · monthly snapshot

Change History

47 versions recorded
  1. Dec 2025 — Present [monthly]

    Completed PHASE2

  2. Sep 2025 — Dec 2025 [monthly]

    Completed PHASE2

  3. Jul 2025 — Sep 2025 [monthly]

    Completed PHASE2

  4. Apr 2025 — Jul 2025 [monthly]

    Completed PHASE2

  5. Feb 2025 — Apr 2025 [monthly]

    Completed PHASE2

Show 42 earlier versions
  1. Jan 2025 — Feb 2025 [monthly]

    Completed PHASE2

  2. Oct 2024 — Jan 2025 [monthly]

    Completed PHASE2

  3. Sep 2024 — Oct 2024 [monthly]

    Completed PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  5. Apr 2024 — Jul 2024 [monthly]

    Completed PHASE2

    Status: Active Not RecruitingCompleted

  6. Mar 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE2

  7. Feb 2024 — Mar 2024 [monthly]

    Active Not Recruiting PHASE2

  8. Jan 2024 — Feb 2024 [monthly]

    Active Not Recruiting PHASE2

  9. Dec 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE2

  10. Nov 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE2

  11. Oct 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE2

  12. Sep 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE2

  13. Aug 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE2

  14. Jul 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE2

  15. Jun 2023 — Jul 2023 [monthly]

    Active Not Recruiting PHASE2

  16. May 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE2

  17. Apr 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE2

  18. Mar 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE2

  19. Feb 2023 — Mar 2023 [monthly]

    Active Not Recruiting PHASE2

  20. Jan 2023 — Feb 2023 [monthly]

    Active Not Recruiting PHASE2

  21. Dec 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE2

  22. Nov 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE2

  23. Sep 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE2

  24. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  25. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE2

  26. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE2

  27. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE2

  28. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE2

  29. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE2

  30. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE2

  31. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE2

  32. Oct 2021 — Dec 2021 [monthly]

    Recruiting PHASE2

  33. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  34. May 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  35. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE2

  36. Feb 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

  37. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE2

  38. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  39. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE2

  40. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  41. Aug 2020 — Oct 2020 [monthly]

    Not Yet Recruiting PHASE2

  42. Jul 2020 — Aug 2020 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Janssen Research & Development, LLC
Data source: Janssen Research & Development, LLC

For direct contact, visit the study record on ClinicalTrials.gov .