deltatrials
Completed PHASE2 INTERVENTIONAL 3-arm NCT04448756

Study of M5049 in Participants With COVID-19 Pneumonia (ANEMONE)

A Phase II, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of M5049 in Hospitalized Participants With COVID-19 Pneumonia (ANEMONE)

Sponsor: EMD Serono Research & Development Institute, Inc.

Interventions M5049 Placebo
Updated 16 times since 2020 Last updated: May 11, 2022 Started: Jul 29, 2020 Primary completion: Aug 16, 2021 Completion: Aug 16, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04448756, this PHASE2 trial focuses on Coronavirus Disease 2019 and remains completed. Sponsored by EMD Serono Research & Development Institute, Inc., it has been updated 16 times since 2020, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Apr 2021 · 59 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Jul 2022 · 9 months · monthly snapshot~Jul 2022 – ~Jul 2024 · 24 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

16 versions recorded
  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  4. Jul 2022 — Jul 2024 [monthly]

    Completed PHASE2

  5. Oct 2021 — Jul 2022 [monthly]

    Completed PHASE2

    Status: Active Not RecruitingCompleted

Show 11 earlier versions
  1. Sep 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  2. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  3. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE2

  4. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE2

  5. Feb 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

  6. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE2

  7. Nov 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  8. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE2

  9. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  10. Aug 2020 — Sep 2020 [monthly]

    Not Yet Recruiting PHASE2

  11. Jul 2020 — Aug 2020 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • EMD Serono Research & Development Institute, Inc.
  • Merck KGaA, Darmstadt, Germany
Data source: EMD Serono

For direct contact, visit the study record on ClinicalTrials.gov .