deltatrials
Recruiting NA INTERVENTIONAL 2-arm NCT04475666

Replacing Protein Via Enteral Nutrition in Critically Ill Patients (REPLENISH)

Replacing Protein Via Enteral Nutrition in a Stepwise Approach in Critically Ill Patients: An International, Multicenter Randomized Controlled Trial

Sponsor: King Abdullah International Medical Research Center

Conditions Critical Illness Nutrition Disorders
Interventions Replenish protein group Standard protein group
Updated 10 times since 2020 Last updated: Aug 31, 2025 Started: Sep 21, 2020 Primary completion: Nov 30, 2025 Completion: Apr 30, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04475666, this NA trial focuses on Critical Illness and Nutrition Disorders and remains actively recruiting participants. Sponsored by King Abdullah International Medical Research Center, it has been updated 10 times since 2020, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshotNot Yet Recruiting~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshotNot Yet Recruiting~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshotNot Yet Recruiting~Mar 2021 – ~Feb 2023 · 23 months · monthly snapshotRecruiting~Feb 2023 – ~Jun 2024 · 16 months · monthly snapshotRecruiting~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotRecruiting~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshotRecruiting~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshotRecruiting~Oct 2025 – present · 11 months · monthly snapshotRecruiting

Change History

10 versions recorded

  1. Oct 2025 — Present [monthly]

    Recruiting NA

  2. Sep 2025 — Oct 2025 [monthly]

    Recruiting NA

  3. Sep 2024 — Sep 2025 [monthly]

    Recruiting NA

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting NA

  5. Jun 2024 — Jul 2024 [monthly]

    Recruiting NA

▶ Show 5 earlier versions

  1. Feb 2023 — Jun 2024 [monthly]

    Recruiting NA

  2. Mar 2021 — Feb 2023 [monthly]

    Recruiting NA

    Status: Not Yet Recruiting → Recruiting

  3. Jan 2021 — Mar 2021 [monthly]

    Not Yet Recruiting NA

  4. Oct 2020 — Jan 2021 [monthly]

    Not Yet Recruiting NA

  5. Aug 2020 — Oct 2020 [monthly]

    Not Yet Recruiting NA

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • King Abdullah International Medical Research Center
Data source: King Abdullah International Medical Research Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations