deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 2-arm NCT04486118

Centrally Acting ACE Inhibition in SLE

A Novel Phase 2 Double-blind, Randomized, Controlled Clinical Trial to Evaluate the Efficacy of Centrally Acting, Non-toxic ACE Inhibition in Cognitive Impairment Associated With SLE

Sponsor: Lupus Research Alliance

Updated 14 times since 2020 Last updated: Sep 18, 2025 Started: Oct 1, 2021 Primary completion: Jun 3, 2025 Completion: Mar 1, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04486118, this PHASE2 trial focuses on Systemic Lupus Erythematosus and remains ongoing. Sponsored by Lupus Research Alliance, it has been updated 14 times since 2021, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Sep 2021 · 5 months · monthly snapshot~Sep 2021 – ~Dec 2021 · 3 months · monthly snapshot~Dec 2021 – ~Jan 2023 · 13 months · monthly snapshot~Jan 2023 – ~May 2023 · 4 months · monthly snapshot~May 2023 – ~Mar 2024 · 10 months · monthly snapshot~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Mar 2025 · 6 months · monthly snapshot~Mar 2025 – ~Sep 2025 · 6 months · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – present · 9 months · monthly snapshot

Change History

14 versions recorded
  1. Oct 2025 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Sep 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE2

  3. Mar 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  4. Sep 2024 — Mar 2025 [monthly]

    Recruiting PHASE2

  5. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

Show 9 earlier versions
  1. Mar 2024 — Jul 2024 [monthly]

    Recruiting PHASE2

  2. May 2023 — Mar 2024 [monthly]

    Recruiting PHASE2

  3. Jan 2023 — May 2023 [monthly]

    Recruiting PHASE2

  4. Dec 2021 — Jan 2023 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  5. Sep 2021 — Dec 2021 [monthly]

    Not Yet Recruiting PHASE2

  6. Apr 2021 — Sep 2021 [monthly]

    Not Yet Recruiting PHASE2

  7. Jan 2021 — Apr 2021 [monthly]

    Not Yet Recruiting PHASE2

  8. Oct 2020 — Jan 2021 [monthly]

    Not Yet Recruiting PHASE2

  9. Aug 2020 — Oct 2020 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Lupus Research Alliance
  • Northwell Health
Data source: Northwell Health

For direct contact, visit the study record on ClinicalTrials.gov .