Efficacy and Safety of Brodalumab Compared With Guselkumab in the Treatment of Plaque Psoriasis After Inadequate Response to Ustekinumab (COBRA)
Efficacy and Safety Comparison of Brodalumab Versus Guselkumab in Adult Subjects With Moderate-to-severe Plaque Psoriasis and Inadequate Response to Ustekinumab
Sponsor: LEO Pharma
Terminated
The recruitment was terminated early due to delays and slow recruitment that significantly jeopardized the trial timelines. There were no safety concerns related to the early termination of the trial.
Other terminated trials from LEO Pharma
Other Plaque Psoriasis trials with similar outcome
Listed as NCT04533737, this PHASE4 trial focuses on Plaque Psoriasis and Psoriasis and remains terminated or withdrawn. Sponsored by LEO Pharma, it has been updated 25 times since 2020, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.
Status Flow
Change History
25 versions recorded-
Sep 2025 — Present [monthly]
Terminated PHASE4
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Apr 2025 — Sep 2025 [monthly]
Terminated PHASE4
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Sep 2024 — Apr 2025 [monthly]
Terminated PHASE4
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Jul 2024 — Sep 2024 [monthly]
Terminated PHASE4
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Mar 2024 — Jul 2024 [monthly]
Terminated PHASE4
▶ Show 20 earlier versions
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Feb 2024 — Mar 2024 [monthly]
Terminated PHASE4
Status: Completed → Terminated
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Feb 2023 — Feb 2024 [monthly]
Completed PHASE4
Status: Active Not Recruiting → Completed
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Dec 2022 — Feb 2023 [monthly]
Active Not Recruiting PHASE4
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Nov 2022 — Dec 2022 [monthly]
Active Not Recruiting PHASE4
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Sep 2022 — Nov 2022 [monthly]
Active Not Recruiting PHASE4
Status: Recruiting → Active Not Recruiting
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Jul 2022 — Sep 2022 [monthly]
Recruiting PHASE4
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Apr 2022 — Jul 2022 [monthly]
Recruiting PHASE4
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Jan 2022 — Apr 2022 [monthly]
Recruiting PHASE4
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Dec 2021 — Jan 2022 [monthly]
Recruiting PHASE4
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Nov 2021 — Dec 2021 [monthly]
Recruiting PHASE4
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Sep 2021 — Nov 2021 [monthly]
Recruiting PHASE4
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Jun 2021 — Sep 2021 [monthly]
Recruiting PHASE4
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May 2021 — Jun 2021 [monthly]
Recruiting PHASE4
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Apr 2021 — May 2021 [monthly]
Recruiting PHASE4
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Mar 2021 — Apr 2021 [monthly]
Recruiting PHASE4
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Feb 2021 — Mar 2021 [monthly]
Recruiting PHASE4
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Jan 2021 — Feb 2021 [monthly]
Recruiting PHASE4
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Dec 2020 — Jan 2021 [monthly]
Recruiting PHASE4
Status: Not Yet Recruiting → Recruiting
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Nov 2020 — Dec 2020 [monthly]
Not Yet Recruiting PHASE4
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Oct 2020 — Nov 2020 [monthly]
Not Yet Recruiting PHASE4
First recorded
Eligibility Summary
No eligibility information available.
Contact Information
- LEO Pharma
For direct contact, visit the study record on ClinicalTrials.gov .
Study Locations
Aachen, Germany , Alicante, Spain , Almere Stad, Netherlands , Amsterdam, Netherlands , Antony, France , Athens, Greece , Augsburg, Germany , Bad Bentheim, Germany , Barcelona, Spain , Bath, United Kingdom and 48 more locations