deltatrials
Terminated PHASE2 INTERVENTIONAL 2-arm NCT04537299

COVID-FIS: Pilot in COVID-19 (SARS-CoV-2) of Fisetin in Older Adults in Nursing Homes (COVID-FIS)

COVID-FIS: A Phase 2 Placebo-Controlled Pilot Study in COVID-19 of Fisetin to Alleviate Dysfunction and Excessive Inflammatory Response in Older Adults in Nursing Homes

Sponsor: Mayo Clinic

Conditions Covid19 SARS-CoV Infection
Interventions Fisetin Placebo
Updated 18 times since 2020 Last updated: Aug 8, 2025 Started: Apr 29, 2022 Primary completion: Aug 31, 2024 Completion: Nov 30, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

The DSMB and NIA determined the study should be stopped due to futility.

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This PHASE2 trial investigates Covid19 and SARS-CoV Infection and is currently terminated or withdrawn. Mayo Clinic leads this study, which shows 18 recorded versions since 2022 — indicating substantial longitudinal coverage. Longitudinal tracking of infectious disease trials helps identify durability of treatment effects.

Status Flow

~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Nov 2021 · 2 months · monthly snapshot~Nov 2021 – ~Feb 2022 · 3 months · monthly snapshot~Feb 2022 – ~Apr 2022 · 59 days · monthly snapshot~Apr 2022 – ~Feb 2023 · 10 months · monthly snapshot~Feb 2023 – ~Dec 2023 · 10 months · monthly snapshot~Dec 2023 – ~May 2024 · 5 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Feb 2025 · 4 months · monthly snapshot~Feb 2025 – ~Sep 2025 · 7 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

18 versions recorded

  1. Sep 2025 — Present [monthly]

    Terminated PHASE2

    Status: Completed → Terminated

  2. Feb 2025 — Sep 2025 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  3. Oct 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

▶ Show 13 earlier versions

  1. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE2

  2. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

    Status: Enrolling By Invitation → Active Not Recruiting

  3. Dec 2023 — May 2024 [monthly]

    Enrolling By Invitation PHASE2

  4. Feb 2023 — Dec 2023 [monthly]

    Enrolling By Invitation PHASE2

  5. Apr 2022 — Feb 2023 [monthly]

    Enrolling By Invitation PHASE2

  6. Feb 2022 — Apr 2022 [monthly]

    Enrolling By Invitation PHASE2

  7. Nov 2021 — Feb 2022 [monthly]

    Enrolling By Invitation PHASE2

  8. Sep 2021 — Nov 2021 [monthly]

    Enrolling By Invitation PHASE2

    Status: Not Yet Recruiting → Enrolling By Invitation

  9. May 2021 — Sep 2021 [monthly]

    Not Yet Recruiting PHASE2

  10. Apr 2021 — May 2021 [monthly]

    Not Yet Recruiting PHASE2

  11. Mar 2021 — Apr 2021 [monthly]

    Not Yet Recruiting PHASE2

  12. Jan 2021 — Mar 2021 [monthly]

    Not Yet Recruiting PHASE2

  13. Oct 2020 — Jan 2021 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Mayo Clinic
  • National Institute on Aging (NIA)
Data source: Mayo Clinic

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations