deltatrials
Suspended PHASE1 INTERVENTIONAL 1-arm NCT04539366

Testing a New Immune Cell Therapy, GD2-Targeted Modified T-cells (GD2CART), in Children, Adolescents, and Young Adults With Relapsed/Refractory Osteosarcoma and Neuroblastoma, The GD2-CAR PERSIST Trial

GD2-CAR PERSIST: Production and Engineering of GD2-Targeted, Receptor Modified T Cells (GD2CART) for Osteosarcoma or Neuroblastoma to Increase Systemic Tumor Exposure

Sponsor: National Cancer Institute (NCI)

Conditions Recurrent Childhood Neuroblastoma Recurrent Childhood Osteosarcoma Recurrent Neuroblastoma Recurrent Osteosarcoma Refractory Childhood Neuroblastoma Refractory Childhood Osteosarcoma Refractory Neuroblastoma Refractory Osteosarcoma
Interventions Biopsy Procedure Biospecimen Collection Bone Marrow Aspiration Bone Marrow Biopsy Cyclophosphamide Echocardiography Test Fludarabine Phosphate GD2-CAR-expressing Autologous T-lymphocytes Imaging Procedure Magnetic Resonance Imaging of the Heart Multigated Acquisition Scan Questionnaire Administration
Updated 33 times since 2020 Last updated: Oct 31, 2025 Started: Jan 25, 2022 Primary completion: Dec 31, 2040 Completion: Dec 31, 2040
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Suspended

Other - review of safety data

This PHASE1 trial investigates Recurrent Childhood Neuroblastoma and Recurrent Childhood Osteosarcoma and is currently suspended. National Cancer Institute (NCI) leads this study, which shows 33 recorded versions since 2022 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Apr 2021 · 59 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Nov 2021 · 2 months · monthly snapshot~Nov 2021 – ~Jan 2022 · 2 months · monthly snapshot~Jan 2022 – ~May 2022 · 4 months · monthly snapshot~May 2022 – ~Jul 2022 · 2 months · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Feb 2023 · 5 months · monthly snapshot~Feb 2023 – ~Apr 2023 · 59 days · monthly snapshot~Apr 2023 – ~Jul 2023 · 3 months · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Oct 2023 · 2 months · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Feb 2024 · 3 months · monthly snapshot~Feb 2024 – ~Jun 2024 · 4 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Jan 2025 · 2 months · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Jul 2025 · 30 days · monthly snapshot~Jul 2025 – ~Aug 2025 · 31 days · monthly snapshot~Aug 2025 – ~Dec 2025 · 4 months · monthly snapshot~Dec 2025 – present · 7 months · monthly snapshot

Change History

33 versions recorded

  1. Dec 2025 — Present [monthly]

    Suspended PHASE1

  2. Aug 2025 — Dec 2025 [monthly]

    Suspended PHASE1

  3. Jul 2025 — Aug 2025 [monthly]

    Suspended PHASE1

  4. Jun 2025 — Jul 2025 [monthly]

    Suspended PHASE1

  5. May 2025 — Jun 2025 [monthly]

    Suspended PHASE1

▶ Show 28 earlier versions

  1. Apr 2025 — May 2025 [monthly]

    Suspended PHASE1

  2. Mar 2025 — Apr 2025 [monthly]

    Suspended PHASE1

  3. Feb 2025 — Mar 2025 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  4. Jan 2025 — Feb 2025 [monthly]

    Recruiting PHASE1

  5. Nov 2024 — Jan 2025 [monthly]

    Recruiting PHASE1

  6. Oct 2024 — Nov 2024 [monthly]

    Recruiting PHASE1

  7. Sep 2024 — Oct 2024 [monthly]

    Recruiting PHASE1

    Status: Suspended → Recruiting

  8. Aug 2024 — Sep 2024 [monthly]

    Suspended PHASE1

  9. Jul 2024 — Aug 2024 [monthly]

    Suspended PHASE1

  10. Jun 2024 — Jul 2024 [monthly]

    Suspended PHASE1

  11. Feb 2024 — Jun 2024 [monthly]

    Suspended PHASE1

  12. Nov 2023 — Feb 2024 [monthly]

    Suspended PHASE1

  13. Oct 2023 — Nov 2023 [monthly]

    Suspended PHASE1

  14. Aug 2023 — Oct 2023 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  15. Jul 2023 — Aug 2023 [monthly]

    Recruiting PHASE1

    Status: Suspended → Recruiting

  16. Apr 2023 — Jul 2023 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  17. Feb 2023 — Apr 2023 [monthly]

    Recruiting PHASE1

  18. Sep 2022 — Feb 2023 [monthly]

    Recruiting PHASE1

  19. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE1

  20. May 2022 — Jul 2022 [monthly]

    Recruiting PHASE1

  21. Jan 2022 — May 2022 [monthly]

    Recruiting PHASE1

  22. Nov 2021 — Jan 2022 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  23. Sep 2021 — Nov 2021 [monthly]

    Not Yet Recruiting PHASE1

  24. May 2021 — Sep 2021 [monthly]

    Not Yet Recruiting PHASE1

  25. Apr 2021 — May 2021 [monthly]

    Not Yet Recruiting PHASE1

  26. Feb 2021 — Apr 2021 [monthly]

    Not Yet Recruiting PHASE1

  27. Jan 2021 — Feb 2021 [monthly]

    Not Yet Recruiting PHASE1

  28. Oct 2020 — Jan 2021 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations