Completed PHASE2/PHASE3 INTERVENTIONAL 1-arm NCT04545307

Transplantation of Allogeneic MSC in Patients With Pulp Necrosis and Chronic Apical Periodontitis (MSC)

Transplantation of Allogeneic Mesenchymal Stromal Cells in Patients With Immature Apex Teeth With Pulp Necrosis and Chronic Apical Periodontitis

Sponsor: Instituto Venezolano de Investigaciones Cientificas

Conditions Apical Periodontitis Pulp Necroses

Interventions Allogenic transplant of BM-MSC in a root canal from patients with immature apexes and pulpar necrosis and apical periodontitis

Updated 5 times since 2020 Last updated: Sep 14, 2020 Started: Nov 27, 2019 Primary completion: Dec 27, 2019 Completion: Jan 27, 2020

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2/PHASE3 clinical study on Apical Periodontitis and Pulp Necroses, this trial is completed. The trial is conducted by Instituto Venezolano de Investigaciones Cientificas and has accumulated 5 data snapshots since 2019. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

Change History

5 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE2/PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE2/PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE2/PHASE3

Phase: PHASE2_PHASE3 → PHASE2/PHASE3
Jan 2021 — Jul 2024 [monthly]

Completed PHASE2_PHASE3
Oct 2020 — Jan 2021 [monthly]

Completed PHASE2_PHASE3

First recorded

Nov 2019

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Instituto Venezolano de Investigaciones Cientificas
Universidad Central de Venezuela

Data source: Universidad Central de Venezuela

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• San Antonio de Los Altos, Venezuela