Recruiting PHASE2 INTERVENTIONAL 2-arm NCT04545424

Trial of Therapeutic Hypothermia in Patients With ARDS (CHILL)

Cooling to Help Injured Lungs (CHILL) Phase IIB Randomized Control Trial of Therapeutic Hypothermia in Patients With ARDS

Sponsor: KAI Research

Conditions Respiratory Distress Syndrome, Adult

Interventions Hypothermia Neuromuscular Blocking Agents Standard of care

Updated 14 times since 2020 Last updated: Nov 5, 2025 Started: Jun 29, 2021 Primary completion: Aug 31, 2026 Completion: Oct 31, 2026

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Respiratory Distress Syndrome, Adult, this trial is actively recruiting participants. The trial is conducted by KAI Research and has accumulated 14 data snapshots since 2021. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

Change History

14 versions recorded

Dec 2025 — Present [monthly]

Recruiting PHASE2
Nov 2024 — Dec 2025 [monthly]

Recruiting PHASE2
Sep 2024 — Nov 2024 [monthly]

Recruiting PHASE2
Jul 2024 — Sep 2024 [monthly]

Recruiting PHASE2
Jun 2024 — Jul 2024 [monthly]

Recruiting PHASE2

▶ Show 9 earlier versions

Dec 2023 — Jun 2024 [monthly]

Recruiting PHASE2
May 2023 — Dec 2023 [monthly]

Recruiting PHASE2
Nov 2022 — May 2023 [monthly]

Recruiting PHASE2
Feb 2022 — Nov 2022 [monthly]

Recruiting PHASE2
Sep 2021 — Feb 2022 [monthly]

Recruiting PHASE2

Status: Not Yet Recruiting → Recruiting
May 2021 — Sep 2021 [monthly]

Not Yet Recruiting PHASE2
Feb 2021 — May 2021 [monthly]

Not Yet Recruiting PHASE2
Jan 2021 — Feb 2021 [monthly]

Not Yet Recruiting PHASE2
Oct 2020 — Jan 2021 [monthly]

Not Yet Recruiting PHASE2

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

KAI Research
US Department of Veterans Affairs Cooperative Studies Program
United States Department of Defense
University of Maryland, Baltimore

Data source: University of Maryland, Baltimore

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Atlanta, United States , Baltimore, United States , Camden, United States , Chicago, United States , Cincinnati, United States , Cleveland, United States , Detroit, United States , Fort Sam Houston, United States , Lexington, United States , Los Angeles, United States and 5 more locations