Sleep Spindles and Memory in Rolandic Epilepsy
Auditory Stimulation Effect on Spindles and Sleep Dependent Learning in Rolandic Epilepsy
Sponsor: Boston University
This observational or N/A phase trial investigates Centrotemporal Epilepsy and Centrotemporal; EEG Spikes, Epilepsy of Childhood and is currently completed. Boston University leads this study, which shows 9 recorded versions since 2021 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.
Study Description(click to expand)This is a prospective study of epilepsy biomarkers in a total of 100 subjects of ages 4-18. Participants will spend about 5 hours at the Massachusetts General Hospital (MGH) Athinoula A. Martinos Center for Biomedical Imaging. They will undergo training on a memory task concurrent with EEG/MEG recordings. During the EEG, subjects will wear headphones that will deliver a quiet pink noise stimulus intermittently during a nap. The auditory stimulus will be calibrated in volume to not cause arousals. After napping, subjects will undergo cognitive testing and memory task testing.
This is a prospective study of epilepsy biomarkers in a total of 100 subjects of ages 4-18. Participants will spend about 5 hours at the Massachusetts General Hospital (MGH) Athinoula A. Martinos Center for Biomedical Imaging. They will undergo training on a memory task concurrent with EEG/MEG recordings. During the EEG, subjects will wear headphones that will deliver a quiet pink noise stimulus intermittently during a nap. The auditory stimulus will be calibrated in volume to not cause arousals. After napping, subjects will undergo cognitive testing and memory task testing.
Status Flow
Change History
9 versions recorded-
May 4, 2026 — Present [daily]
Completed
Status: Recruiting → Completed · Phase: NA → None
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Dec 2024 — May 2026 [monthly]
Recruiting NA
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Sep 2024 — Dec 2024 [monthly]
Recruiting NA
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Jul 2024 — Sep 2024 [monthly]
Recruiting NA
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Jul 2023 — Jul 2024 [monthly]
Recruiting NA
▶ Show 4 earlier versions
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May 2022 — Jul 2023 [monthly]
Recruiting NA
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Mar 2021 — May 2022 [monthly]
Recruiting NA
Status: Not Yet Recruiting → Recruiting
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Jan 2021 — Mar 2021 [monthly]
Not Yet Recruiting NA
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Oct 2020 — Jan 2021 [monthly]
Not Yet Recruiting NA
First recorded
Eligibility Summary
The investigators are recruiting children with Rolandic epilepsy and children without epilepsy (aged 4 years old and above) for a non-invasive brain imaging study using Magnetic Resonance Imaging (MRI), Magnetoencephalography/Electroencephalography (MEG/EEG), and experimental tasks. The investigators hope to determine the brain circuits and brain rhythms affected in these children and ultimately identify new treatment options for childhood epilepsy patients.
Contact Information
- Boston University
- Massachusetts General Hospital
- National Institute of Neurological Disorders and Stroke (NINDS)
For direct contact, visit the study record on ClinicalTrials.gov .