deltatrials
Recruiting PHASE4 INTERVENTIONAL 7-arm NCT04604509

Nicotine Replacement Therapy, Counseling, Varenicline, and Bupropion for Smoking Cessation, the PISCES I Trial

PISCES I: Precision Implemented Smoking Cessation Evaluation Study

Sponsor: M.D. Anderson Cancer Center

Conditions Cigarette Smoking-Related Carcinoma
Interventions Bupropion Hydrochloride Controlled-release Nicotine Replacement Questionnaire Administration Tobacco Cessation Counseling Varenicline
Updated 11 times since 2020 Last updated: Oct 10, 2025 Started: Aug 4, 2020 Primary completion: Dec 31, 2028 Completion: Dec 31, 2028
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE4 clinical study on Cigarette Smoking-Related Carcinoma, this trial is actively recruiting participants. The trial is conducted by M.D. Anderson Cancer Center and has accumulated 11 data snapshots since 2020. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshotRecruiting~Jan 2021 – ~Feb 2023 · 25 months · monthly snapshotRecruiting~Feb 2023 – ~Nov 2023 · 9 months · monthly snapshotUnknown Status~Nov 2023 – ~Apr 2024 · 5 months · monthly snapshotRecruiting~Apr 2024 – ~May 2024 · 30 days · monthly snapshotRecruiting~May 2024 – ~Jul 2024 · 2 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotRecruiting~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshotRecruiting~Oct 2024 – ~May 2025 · 7 months · monthly snapshotRecruiting~May 2025 – ~Nov 2025 · 6 months · monthly snapshotRecruiting~Nov 2025 – present · 8 months · monthly snapshotRecruiting

Change History

11 versions recorded

  1. Nov 2025 — Present [monthly]

    Recruiting PHASE4

  2. May 2025 — Nov 2025 [monthly]

    Recruiting PHASE4

  3. Oct 2024 — May 2025 [monthly]

    Recruiting PHASE4

  4. Sep 2024 — Oct 2024 [monthly]

    Recruiting PHASE4

  5. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE4

▶ Show 6 earlier versions

  1. May 2024 — Jul 2024 [monthly]

    Recruiting PHASE4

  2. Apr 2024 — May 2024 [monthly]

    Recruiting PHASE4

  3. Nov 2023 — Apr 2024 [monthly]

    Recruiting PHASE4

    Status: Unknown Status → Recruiting

  4. Feb 2023 — Nov 2023 [monthly]

    Unknown Status PHASE4

    Status: Recruiting → Unknown Status

  5. Jan 2021 — Feb 2023 [monthly]

    Recruiting PHASE4

  6. Nov 2020 — Jan 2021 [monthly]

    Recruiting PHASE4

    First recorded

Aug 2020

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • M.D. Anderson Cancer Center
  • National Cancer Institute (NCI)
Data source: M.D. Anderson Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations