deltatrials
Completed PHASE1 NCT04609826

A Study of JNJ-74856665 in Participants With Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)

A Phase 1, FIH, Dose Escalation Study of JNJ-74856665 (Dihydroorotate Dehydrogenase [DHODH] Inhibitor) Alone or in Combination in Participants With AML or MDS

Sponsor: Janssen Research & Development, LLC

Conditions Acute Myeloid Leukemia Chronic Myelomonocytic Leukemia Myelodysplastic Syndromes
Interventions AZA JNJ-74856665 VEN
Updated 51 times since 2020 Last updated: Sep 30, 2025 Started: Nov 26, 2020 Primary completion: Aug 25, 2025 Completion: Aug 25, 2025

Listed as NCT04609826, this PHASE1 trial focuses on Acute Myeloid Leukemia and Chronic Myelomonocytic Leukemia and remains completed. Sponsored by Janssen Research & Development, LLC, it has been updated 51 times since 2020, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Jun 2021 · 3 months · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~May 2023 · 2 months · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Jan 2025 · 2 months · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Aug 2025 · 2 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Nov 2025 · 2 months · monthly snapshot~Nov 2025 – present · 5 months · monthly snapshot

Change History

51 versions recorded

  1. Nov 2025 — Present [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  2. Sep 2025 — Nov 2025 [monthly]

    Active Not Recruiting PHASE1

  3. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Jun 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE1

  5. May 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE1

▶ Show 46 earlier versions

  1. Apr 2025 — May 2025 [monthly]

    Active Not Recruiting PHASE1

  2. Mar 2025 — Apr 2025 [monthly]

    Active Not Recruiting PHASE1

  3. Feb 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Jan 2025 — Feb 2025 [monthly]

    Active Not Recruiting PHASE1

  5. Nov 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE1

  6. Oct 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE1

  7. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE1

  8. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  9. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE1

  10. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

  11. May 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE1

  12. Apr 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE1

  13. Mar 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE1

  14. Feb 2024 — Mar 2024 [monthly]

    Active Not Recruiting PHASE1

  15. Jan 2024 — Feb 2024 [monthly]

    Active Not Recruiting PHASE1

  16. Dec 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE1

  17. Nov 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE1

  18. Oct 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE1

  19. Sep 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE1

  20. Aug 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE1

  21. Jul 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE1

  22. Jun 2023 — Jul 2023 [monthly]

    Active Not Recruiting PHASE1

  23. May 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE1

  24. Mar 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE1

  25. Feb 2023 — Mar 2023 [monthly]

    Active Not Recruiting PHASE1

  26. Jan 2023 — Feb 2023 [monthly]

    Active Not Recruiting PHASE1

  27. Dec 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE1

  28. Nov 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE1

  29. Sep 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  30. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE1

  31. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE1

  32. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE1

  33. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE1

  34. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE1

  35. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE1

  36. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE1

  37. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE1

  38. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE1

  39. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE1

  40. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE1

  41. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  42. Mar 2021 — Jun 2021 [monthly]

    Recruiting PHASE1

  43. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE1

  44. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  45. Dec 2020 — Jan 2021 [monthly]

    Not Yet Recruiting PHASE1

  46. Nov 2020 — Dec 2020 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Janssen Research & Development, LLC
Data source: Janssen Research & Development, LLC

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Barcelona, Spain , Leicester, United Kingdom , London, United Kingdom , Madrid, Spain , Manchester, United Kingdom , Nice, France , Pamplona, Spain , Paris, France , Pessac, France , Santander, Spain and 3 more locations